27k Accesses 12 Citations 174 Altmetric Metrics details An Author Correction to this article was published on 29 April 2024This article has been updatedAbstract Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic ...
18k Accesses 92 Citations 90 Altmetric Metrics details Abstract Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF) binding and requires nucleosomal reorganization. However, it remains unclear how dynamic this process is. In the present study, we use small-...
8930 Accesses 47 Citations 28 Altmetric Metrics details Abstract Direct cardiac reprogramming of fibroblasts to cardiomyocytes presents an attractive therapeutic strategy to restore cardiac function following injury. Cardiac reprogramming was initially achieved through overexpression of the transcription factors ...
17k Accesses 125 Altmetric Metrics details Abstract ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as SMARCA4) subunit responsible for...
12k Accesses 41 Altmetric Metrics details Abstract Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs)1,2. In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC3 contains 16 subunits,...
5437 Accesses 5 Altmetric Metrics details Abstract Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodelling complexes are multi-protein machineries that control gene expression by regulating chromatin structure in eukaryotes. However, the full subunit composition of SWI/SNF complexes in ...
38k Accesses 27 Altmetric Metrics details Abstract Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex occurs at very high frequencies in a variety of human malignancies, suggesting a widespread role for the SWI/SNF complex in tumour suppression1. However, the ...
Metrics Abstract By exome sequencing, we foundde novo SMARCB1mutations in two of five individuals with typical Coffin-Siris syndrome (CSS), a rare autosomal dominant anomaly syndrome. AsSMARCB1encodes a subunit of the SWItch/Sucrose NonFermenting (SWI/SNF) complex, we screened 15 other genes enc...
10k Accesses 154 Citations 33 Altmetric Metrics details Abstract Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation of therapeutic response are required. Our prospective analyses of patients within the AIM study revealed ...
10k Accesses 89 Altmetric Metrics details An Author Correction to this article was published on 03 December 2020 This article has been updatedAbstract Interactions between chromatin-associated proteins and the histone landscape play major roles in dictating genome topology and gene expression. Cancer-spe...