Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF) binding and requires nucleosomal reorganization. However, it remains unclear how dynamic this process is. In the present study, we use small-molecule inhibitio
Similar log2 values of intensities indicate minimal sample loading bias in both datasets. The boxplots of ubiquitinome and proteome were from n = 44,752 Peptide Spectrum Matches (PSMs) and n = 390,548 PSMs respectively. The box plots indicate the median (centre line), the third ...
Smarcd2-deficient mice fail to generate functionally mature neutrophils and eosinophils, a phenotype reminiscent of neutrophil-specific granule deficiency (SGD) in humans, for which loss-of-function mutations in CEBPE (encoding CEBPɛ) have been reported. SMARCD2-containing SWI/SNF complexes are ...
CRISPR-Cas9 datasets (Avana-19Q3) were obtained from the Project Achilles data portal (https://depmap.org/portal/achilles/). Fitness (CERES) scores were extracted for each cell line and hierarchical clustering was performed using complete linkage and correlation as a distance measure. Heatmaps we...
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery Cheng-cen Guo H. Eric Xu Xiong Ma Acta Pharmacologica Sinica(2023) Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus ...
acc=GSE108025, respectively. The fitness data were derived from Project Achilles through the Project Achilles Data Portal (https://portals.broadinstitute.org/achilles/about). The dataset derived from this resource that supports the findings of this study is available athttps://portals.broadinstitute...
a Correlation plot showing SWINGN and GAS6 expression (as FPKM+ pseudocount values) in LUSC samples (n = 552) from TCGA database (gdc-portal.nci.nih.gov). Correlation p-value is calculated using a t-distribution. b, c RT-qPCR (b) and Western blot (c) analysis of H226 lung ...
Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodelling complexes are multi-protein machineries that control gene expression by regulating chromatin structure in eukaryotes. However, the full subunit composition of SWI/SNF complexes in plants remains unclear. Here we report that in Arabid...
RNA-seq data and Gleason score from the TCGA PCa dataset were retrieved from the TCGA data portal using TCGAbiolinks R package v2.12.293. Immunohistochemistry Immunohistochemistry (IHC) was performed on sections of formalin-fixed paraffin-embedded patient tissue (FFPE) using a Bond III automated ...
Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation of therapeutic response are required. Our prospective analyses of patients within the AIM study revealed genomic profiles that clearly dichotomized responders and nonresponders....