The substitution reaction of the diethyl allylic and propargylic phosphates with Ar2CH anions was applied to sec‐alkyl phosphates to compare reactivity and stereoselectivity. However, the substitution took place on the ethyl carbon of the diethyl phosphate group. We then found that the diphenyl ...
So I understand clearly the nucleophilic substitution reactions, but I am wondering if anyone is familiar with any sn2 reaction that can be forced into a retention of stereochemistry? I am speaking of ring substituents, mainly. Is there a possiblity of having a large enough substiuent to cause...
cyclohexane derivativeshydrocarbons (benzene compoundsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option....
Sharma , R. Pandey , G. Pandey , R. Lal , M. L. Coote et al. 2011 . Competing SN2 and E2 reaction pathways for hexachlorocyclohexane degradation in gas phase, solution and enzymes . Chemical Communications (doi: TODO: clickthrough URL 10.1039/C0CC02925D )....
Machaerium multiflorum spruce (Fabaceae) (Scheme 1).[2] Although much effort has been devoted to the synthesis of this class of natural products,[3] the stereocontrolled construction of the three or four stereocenters located on the cyclohexane ring still represents a significant synthetic challenge...
Synthetic application was demonstrated when (S)-citronellal was treated with rac-1a in the presence of 2b to give 12 as a single diastereomer, which was further cyclized to give a tetrasubstituted cyclohexane derivative 13 with excellent stereoselectivity. Transition-state models were proposed to ...
cyclohexane derivativesdiastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)cycloaddition reactionspyran derivativesThe reaction of 6-bromo-2-hexenoates with active methylene compounds proceeds via formal [4 + 1]-annulation and affords highly functionalized cyclopentanes with up ...