The elimination of I− generated an aryl radical C, which further reacts with S3.- to deliver the intermediate D. The homolysis of D affords a thiyl radical E and S2.-. Intramolecular radical addition in E produce the radical F, which experience the electron transfer with A to de...
The addition of HCN to monosubstituted cyclohexanones yielding cyanohydrins is strongly catalyzed by hydroxynitrile lyases (HNLs). With PaHNL from bitter almonds, the addition to 2-alkyl cyclohexanones 1bg is highly ()-selective, whereas the methyl compound 1a reacts ()-selectively. With MeHNL ...
The reaction is carried out under precisely controlled temperature conditions and cyanide feed rate profiles to maintain a reasonably constant concentration of non-reacted cyanide, thereby minimizing the formation of undesirable diisophorone, its nitrile derivative(s) and HCN polymers. A polyacidic acid...
The reaction is carried out under precisely controlled temperature conditions and cyanide feed rate profiles to maintain a reasonably constant concentration of non-reacted cyanide, thereby minimizing the formation of undesirable diisophorone, its nitrile derivative(s) and HCN polymers. A polyacidic acid...