In conclusion, we suggest in the inflammatory pain state, CCL2 can act on small-diameter DRG neurons, leading to upregulation of HCN2 expression and consequently Ih, which in turn leads to neuronal hyperexcitability.doi:10.3389/fnmol.2023.1144614Lamei Li...
The cytokine growth-related oncogene (GRO/KC; CXCL1) shows strong, rapid upregulation in dorsal root ganglion (DRG) in both nerve injury and inflammatory pain models. We examined the direct effects of GRO/KC on small diameter DRG neurons, which are predominantly nociceptive. Whole cell voltage...
Tetrodotoxin-resistant (TTX-R) sodium current in small-size dorsal root ganglia (DRG) neurons is upregulated by prostaglandin E(2) and serotonin through a protein kinase A (PKA)/protein kinase (PKC) pathway, suggesting G protein modulation of one or more TTX-R channels in these neurons. Rec...
PIEZO1 Is Selectively Expressed in Small Diameter Mouse DRG Neurons Distinct From Neurons Strongly Expressing TRPV1 来自 科研支点 喜欢 0 阅读量: 35 作者:J Wang,JH La,OP Hamill 摘要: Using a high resolution functional test for the selective expression, we found that Yoda1, a PIEZO1-specific...
In this study, we investigated the modulation of another TTX-R channel, Na(v)1.8, by GTP(gammaS) in small-diameter DRG neurons from rats using whole-cell voltage clamp recordings. Because it has been suggested that fluoride, often used in intracellular recording solutions, may bind to trace...
B. Jr ( 2009 ) Small diameter DRG neurons exhibit increased low-voltage activated T-type calcium currents in experimental diabetes . J. Periph. Nerv. Syst. 14 , 135.Shankarappa S. A., Piedras-Renteria E. S. and Stubbs E. B. Jr (2009) Small diameter DRG neurons ...
The application of the CCR2 agonist to normal T9鈥揟11 small-diameter DRG neurons simulates the changes in the gating properties of T-type Ca2+ channel that occur in the GU group. Conclusions: Therefore, these findings indicate that CCR2 may function as a critical regulator in the ...
The application of the CCR2 agonist to normal T9鈥揟11 small-diameter DRG neurons simulates the changes in the gating properties of T-type Ca2+ channel that occur in the GU group. Conclusions: Therefore, these findings indicate that CCR2 may function as a critical regulator in the ...
We recorded neuronal responses from the ex-vivo preparations of the dorsal root ganglia (DRG) one week following a chronic constriction injury (CCI) of the sciatic nerve in adult rats. We found that small diameter DRG neurons (30 碌m) were unaffected. Puff application of either glutamate, or...
Chol- ine acetyltransferase-like immunoreactivity in small diam- eter neurons of the rat dorsal root ganglion. Neurosci Lett 1995; 198:17-20.Sann H, McCarthy PW, Mader M, Schemann M (1995) Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ...