The predominant role of APP-Aβ degradation genes was further confirmed by RNA sequencing data in a mouse model of mainly subcortical ischemia, mimicking small vessel ischemic disease, where only genes belonging to the APP-Aβ degradation path (A2m,Plat,Ctsd,CtsbandKlk6) were significantly overex...
but the longer-term pathologic, including gliovascular alterations, and radiologic consequences of hypoperfusion have not yet been fully investigated. Although there is no association between carotid stenosis and SVD in humans, 25 small vessel changes have been linked to histologic features that have ...
2) Subcortical ischemic vascular dementia, 3) Multi-infarct dementia, and 4) Mixed dementia [4] (Fig.1). Post-stroke dementia is a major consequence after large vessel strokes. Approximately 10% of patients develop
Rene´ IF de Coo6, Jan C den Hollander7, Renske Oegema1, Douglas B Gould4 and Grazia MS Mancini*,1 Familial porencephaly, leukoencephalopathy and small-vessel disease belong to the spectrum of disorders ascribed to dominant mutations in the gene encoding for type IV collagen alpha-1 (COL...
(AS), any ischemic stroke (AIS) and small vessel stroke (SVS). The WMH locus on chromosome 13 (top SNP: rs11838776) was shared between WMH and SVS. These two loci were not significantly associated at GWAS significance with SVS in the MEGASTROKE study (rs17433120:p = 2.059 ×...
Cerebral small vessel disease (CSVD) accounts for nearly 20% of all ischemic strokes and is associated with a high risk of vascular dementia [1, 2]. Type-2 diabetes mellitus (T2DM) is a well-established risk factor for cerebrovascular diseases, such as ischemic stroke [3, 4]. Recent studi...
(LAD) could predict the presence of cerebral small vessel disease (cSVD) in patients older than 65 years with atrial fibrillation as the cause of ischemic stroke.Materials and methodsIn this study, we included patients over 65 years of...
Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emerging as a major homogeneous subtype. Its progre
SVID, small vessel ischemic disease; VaD, vascular dementia; BCCAS, bilateral common carotid artery stenosis; LOAD, late-onset Alzheimer's disease; GWAS, genome-wide association study. CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, CD2AP). They shed light on critical LOAD pathogenic path- ...
These mechanisms make macrovessel remodeling a significant factor in ischemic stroke, which is the number one cause of stroke and impaired remodeling. The decreased CBF and/or ischemic stroke result in increased redox stress, neuroinflammation, neurodegeneration and vascular cognitive impairment or ...