The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease. Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS) is a phase II randomised double-blind crossover trial. In ...
FDa = arteriolar fractal dimension; VRF = vascular risk factor; WMH = white matter hyperintensities; SVD = small vessel disease. Dashed lines represent non-significant associations. Full size image We tested additional SEMs—to test for co-association of retinal and SVD ...
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the LACunar Intervention Trial-2 (LACI-2) (ISRCTN14911850). medRxiv. 2022.05.31.22275743. doi:10.1101/2022.05.31.22275743Google Scholar 12. Bath...
a Cerebral small vessel disease (SVD) was quantified on 3T MRI using four imaging markers: white matter hyperintensities, lacunes, enlarged perivascular spaces, and cerebral microbleeds. b Midlife risk factors were classified into two categories: non-modifiable (inherited) risk vs. modifiable risk ...
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter hyperintensities (N = 42,310), fractional anis...
0.104% in PBS; 0.34% in HSA FLI / Monitoring thrombosis, peripheral arterial disease, tumor angiogenesis, and lymphatic drainage; imaging- guided tumor resection and sentinel lymph node biopsy Li et al.95 p-FE PS-g-PEG / 760/1,010 1.65% in water FLI / 3D vessel imaging and tumor imagin...
Gd-encap- sulated carbonaceous dots for accurate characterization of tumor vessel permeability in magnetic resonance imaging. Nanomedicine. 2019;21:102074. 34. Yang HM, Park CW, Park S, Kim JD. Cross-linked magnetic nanoparticles with a biocompatible amide bond for cancer-targeted dual optical/...
Urgent surgical exploration is indicated when total or partial early vessel obstruction is suspected. Different surgical procedures have been described depending on the site of obstruction. One option for any vascular thrombosis is to perform a graft nephrectomy, re-preservation with cold organ preservati...
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white matter hyperintensities) al
Glaucoma is a neurodegenerative disease that leads to irreversible retinal ganglion cell (RGC) loss and is one of the main causes of blindness worldwide. The pathogenesis of glaucoma remains unclear, and novel approaches for neuroprotective treatments are urgently needed. Previous studies have revealed...