The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease. Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS) is a phase II randomised double-blind crossover trial. In ...
FDa = arteriolar fractal dimension; VRF = vascular risk factor; WMH = white matter hyperintensities; SVD = small vessel disease. Dashed lines represent non-significant associations. Full size image We tested additional SEMs—to test for co-association of retinal and SVD ...
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited to older cohorts wherein pathologies of both dementia (e.g. amyloid) and SVD (e.g. white matter hyperintensities) al
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the LACunar Intervention Trial-2 (LACI-2) (ISRCTN14911850). medRxiv. 2022.05.31.22275743. doi:10.1101/2022.05.31.22275743Google Scholar 12. Bath...
a Cerebral small vessel disease (SVD) was quantified on 3T MRI using four imaging markers: white matter hyperintensities, lacunes, enlarged perivascular spaces, and cerebral microbleeds. b Midlife risk factors were classified into two categories: non-modifiable (inherited) risk vs. modifiable risk ...
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter hyperintensities (N = 42,310), fractional anis...
Gd-encap- sulated carbonaceous dots for accurate characterization of tumor vessel permeability in magnetic resonance imaging. Nanomedicine. 2019;21:102074. 34. Yang HM, Park CW, Park S, Kim JD. Cross-linked magnetic nanoparticles with a biocompatible amide bond for cancer-targeted dual optical/...
It remains to be tested whether p21-dependent quiescence could contribute to invasion and metastasis in NSCLC, but if it does, then this provides another rationale for targeting p21 function in the disease. Even after knocking out p21 in TP53WT NSCLC cell lines, there was often a small ...
The reaction was carried out in an open vessel at 65 °C (10 W) for 20 min. After completing the reaction, acetone was removed under reduced pressure, and the product was extracted using ethyl acetate. The organic layer was dried over sodium sulfate, and the solvent was removed on ...
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden macrophages in the vessel wall. One of the major transcription factors in inflammation is nuclear factor κB (NF-κB), and we have studied its role in the development of atherosclerosis. Bone marrow fr...