Subclinical brain changes in Alzheimer's disease (AD) are detectable many years before symptom onset. While cerebral small vessel disease (SVD) has been well‐established as a key pathology in AD, whether genetic predisposition to AD influences markers of SVD in midlife remains unclear. In this ...
Global small vessel disease brain changes predict cognitive declinedoi:10.1038/s41582-019-0296-8Ian FyfeNature Reviews Neurology
To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy.Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 patients ...
To investigate the association between vascular risk factors and progression of cerebral small vessel disease (SVD), we conducted a longitudinal study with neurologically healthy cohort composed mostly of middle-aged adults (n = 665, mean age, 57.7 years). Subjects, who had both baseline data...
Subtle blood-brain ... JM Wardlaw,SJ Makin,MCV Hernández,... - 《Alzheimers & Dementia》 被引量: 33发表: 2017年 White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline. In patients with subjective cognitive decline, we assessed whether small vessel disease was...
摘要 Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is c...展开更多 作者 Ruxue Jia Gemma Solé-Guardia Amanda J.Kiliaan 机构地区 Department of Medical Imaging 出处 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1233-1240,共...
reveal surrogate markers of SVD progression37. After stroke, medial temporal lobe atrophy is rather related to cognitive impairment than markers of small vessel disease38. When small vessel disease causes subcortical VaD, this is associated with the pathology of Binswanger's disease39....
et al. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology 78, 1785–1792 (2012). Article PubMed CAS Google Scholar Schmidt, R. et al. White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention ...
Cerebral small vessel disease (CSVD) is defined as a group of CSVD, in which cerebral small arteries, arterioles, capillaries, venules, small veins are attributed to atherosclerotic, genetic, idiopathic, infectious, immune-mediated or other secondary etiologies1. The age-related CSVD includes deep ...
A homozygous \\{NOTCH3\\} mutation p.R544C and a heterozygous \\{TREX1\\} variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain "A homozygous NOTCH3 muta- tion p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel...