By December 2020, 89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration (NMPA) of China. Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug ...
Explore BPS Bioscience’s small molecule cancer therapy targets for advanced research in targeted treatments. Discover our range of compounds designed to inhibit key cancer-related pathways and enhance therapeutic strategies.
Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug resistance. To better promote the development of targeted anti-cancer drugs, we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according ...
In present study we have assessed prospects of significant proteins which are known to be targeted by number of small molecules and related drugs for effective treatment of various forms of cancer. Moreover, we also addressed the efficacies of these drugs toward the cancer treatment and future ...
Targeted therapy drugs 1. Introduction Monoclonal antibodies and small molecule inhibitors are the two major types of targeted therapies. While monoclonal antibodies block the extracellular components of target proteins, small molecule inhibitors are highly cell permeable and can enter cells, thereby blockin...
learning classifiers were applied for the prediction of new small molecular modulators of the SARS-CoV-2 S protein RBD–ACE2 interaction. Using this RBD: hACE2 predictor, they identified more than 300 novel small molecule scaffolds that can be repurposed for SARS-CoV-2. Panda et al. took ...
learning classifiers were applied for the prediction of new small molecular modulators of the SARS-CoV-2 S protein RBD–ACE2 interaction. Using this RBD: hACE2 predictor, they identified more than 300 novel small molecule scaffolds that can be repurposed for SARS-CoV-2. Panda et al. took ...
Scientists are one step closer to developing a targeted therapy for lymphoma. New research, published by Cell Press in the April 13th issue of the journal Cancer Cell, identifies a specific small-molecule inhibitor that was nontoxic in animal experiments
Key discoveries in, and the availability of small molecule kinase inhibitors and antibodies as targeted and immunotherapy, alone and in combination, have improved survival and quality of life for many patients with advanced melanoma, but many challenges, such as the development of resistance and varyi...
Collectively, our study identified that TOP3β is essential for the survival of colon cancer cells, it is also a functional target of small molecule CBG. CBG induced TOP3β-dependent phenotypes in cancer cells, including formation of stress granules, R-loop and DNA damage. Our findings not on...