small moleculeImmunotherapy shows promise for positively changing the landscape of the management of many advanced solid tumors, including gastrointestinal (GI) malignancies. Many of these developments have been focused on vaccine-based, monoclonal antibody therapies and more recently, checkpoint inhibitors,...
The hypoxic environment of solid tumours creates a hypoxia–adenosinergic axis of gene regulation, which enforces tumour immune tolerance and can be targeted by small-molecule drugs. Small-molecule immunotherapy for cancer is a growing area ripe with opportunity for exploitation of critical immune biolo...
Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to ...
Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis. J Biol Chem (2014) 289:16508-15. doi:10.1074/ jbc.M114.558098... D Bhattacharya,VP Dwivedi,M Maiga,... - 《Journal of Biological Chemistry》 被引量: 41发表: 2014年 Anti-TNF immunotherapy reduces CD8...
Small-molecule drugs are chemical compounds with a molecular weight in the range of 0.1–1 kDa. They are smaller than biologics or bio-therapeutic modalities, which are generally more than 1 kDa in molecular size, as shown in Fig. 6.2. Owing to the small size, they possess an advantage ov...
The advent of new small molecule therapies that act on intracellular signaling contributes to a revolution in the treatment of several dermatological diseases. Its use in inflammatory, neoplastic and even infectious diseases shows the versatility of these new therapies and is already a reality for pati...
Unsatisfactory physicochemical properties of macromolecular drugs seriously hinder their application in tumor immunotherapy. However, these problems can be effectively solved by small-molecule compounds. In the promising field of small-molecule drug development, proteolysis targeting chimera (PROTAC) offers a...
The antibody transfers and optimally releases the antitumor small molecule at the cancerous target site, achieving therapeutic function without affecting healthy cells (49). This class of drugs is simply a classic meeting point of chemotherapy and immunotherapy in healthcare (50). Download: Download ...
Fosun Pharma takes pharmaceutical manufacturing as its core business and sticks to innovative research and development. Through in-house R&D, co-development, in-licensing and incubation, Fosun Pharma has established platforms for small molecule innovative drugs, antibody drugs and cell therapy, focusing ...
Virtual screening identifies potential small molecule drugs for cancer immunotherapy The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers. ...