However, the model is not optimal because mice develop mostly small intestine tumors [224]. Tumor number in female ApcMin/+ mice at 4–5 weeks of age is not affected by 10 weeks of treatment with 1,25(OH)2D3 or its analogs 1,25(OH)216-ene-19-nor-24-oxo-D3 (Ro 26-9114)....
W. (1962). The histology of the mucosa of the small intestine of the long-nosed bandicoot (Marsupialia: Perameles nasuta Geoffroy) with special reference to intestinal secretion. Acta Anat ., 50 , 73–89.Lennep , E.W. van: The histology of the mucosa of the small intestine of the ...
11 Immunohistochemical stains that use antibodies against c-Kit allow the ICC to be labeled. The distribution and onset of appearance of these cells in the gastrointestinal tract have been described.10 Figure 96-7. Photomicrograph showing the interstitial cells of Cajal in the small ...
Different immune cells, including lymphocytes, macrophages, and dendritic cells, constitutively enter the small intestine to sustain local populations. Lymphocyte migration into the small intestine generally relies on β7-integrin and the chemokine receptor CCR930,31, but it is not known if the same ...
Results are depicted as the means of five independent stretches of proximal small intestine totaling >300 crypts. Most Cre LacZ-labeled cells occurred at stem cell positions 1′ and 2′, which are highly similar to the positions where Lgr5 stem cells reside. Quantitative data on the start ...
Human interleukin-22 (IL-22) is known as a “dual function” cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens. On the other hand, the ov
Development of the small intestine in the hypophysectomized rat. II. Influence of cortisone, thyroxine, growth hormone, and prolactin. (1975) Development of the small intestine in the hypophysectomized rat: I. Crowth, histology, and activity of alkaline phospha- tase, maltase, and ... ...
The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, an
Additional cases of low-grade PNETs, as well as neuroendocrine tumors of the rectum and small intestine (Alvarez et al., 2018), both fell in the same pattern of having low proliferation but high neuroendocrine features (Figure S5D). Taken together, these results support that MAds derive ...
Gastrointestinal toxicity is a major concern in the development of drugs. Here, we establish the ability to use murine small and large intestine-derived monolayers to screen drugs for toxicity. As a proof-of-concept, we applied this system to assess gast