Monocyte to HDL cholesterol ratio showed a positive quantitative association with all types of cerebral small vessel disease, including white matter intensity volume (P < 0.001), lacunes (P < 0.001), and cerebral microbleed (P < 0.001) Full size image Table 2 Comparisons of ...
microbleedTo assess whether neuroimaging markers of chronic cerebral small vessel disease (cSVDm) influence early recovery after acute ischemic stroke (AIS). Retrospective analysis of patients diagnosed with AIS and included in the Spanish Neurological Society Stroke Database. (1) Brain MRI performed ...
All subjects underwent 3.0-Tesla brain MRI (Intera; Philips Medical Systems, Best, Netherlands), including susceptibility-weighted imaging, fluid-attenuated inversion recovery imaging (FLAIR), and T1-/T2-weighted imaging, obtained with the spin-echo technique. The repetition time for the T2-images w...
for each of the following findings to estimate cSVD score: severe white matter hyperintensities (periventricular Fazekas grade 2 or 3); ≥ 1 lacunar infarcts; ≥ 1 cerebral microbleed; and > 10 perivascular spaces visible in the basal ganglia on at least one side of the brain....
white matter hyperintensities are nonspecific to small vessel disease and can co-occur with other brain diseases. Advanced neuroimaging techniques at the ultrahigh field magnetic resonance imaging are enabling improved characterization, identification of cerebral small vessel disease and are elucidating some ...
The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology. 2009;73:1759–66. Article PubMed CAS Google Scholar Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al. Neuroimaging standards for research into small vessel...
the images show cerebral microbleed on SWI, white matter hyperintensities on FLAIR, lacunar infarction on FLAIR, and enlarged perivascular space of basal ganglia on T2WI. Abbreviations: SWI: susceptibility weighted imaging; FLAIR: fluid-attenuated inversion recovery imaging; T2WI: T2-weighted imaging. ...
Cerebral microbleeds (CMBs) were identified as small focal rounded hypointense lesions, graded based on susceptibility-weighted imaging sequences using the Brain Observer MicroBleed Scale [30]. Medial temporal lobe atrophy (MTA) was graded by coronal sections on a 5-point Scheltens’ scale (0—...
We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, p = 0.003), microbleed (adjusted r = 0.102, p = 0.006), and...
had demonstrated that glutamate an excitatory neurotransmitter could activate MMP-2 and MMP-9 in isolated brain capillaries [241]. A similar increase in glutamate surge occurs during reperfusion to the micro-ischemic area resulting in further enhancement of blood barrier leakages and causing microbleed...