Gastrointestinal toxicity is a major concern in the development of drugs. Here, we establish the ability to use murine small and large intestine-derived monolayers to screen drugs for toxicity. As a proof-of-concept, we applied this system to assess gastrointestinal toxicity of ~50 clinically used...
Indeed, it was found that, in contrast to humans, cells in the small intestine of mice undergo more stem cell divisions than in the large intestine [132]. However, it is important to note that the differences in the location of intestinal cancers between mice and humans may also be du...
1995. Digestion of soybean meal protein in the equine small and large intestine at varying levels of intake. J. Equine Vet. Sci. 15:391-397.Farley EB, Potter GD, Gibbs PG, et al. (1995) Digestion of soy- bean meal protein in the equine small and large intestine. Proc 14th Equine ...
The small and large intestine share certain histologic characteristics. The wall of the small intestine and colon is composed of four layers: mucosa (or mucous membrane), submucosa, muscularis (or muscularis propria), and adventitia (or serosa) (Fig. 96-2). Figure 96-2. Photomi...
intestinal transit data of a liquid meal labeled by a nonabsorbable marker,14C-polyethylene glycol, it is apparent that the proximal small intestine has a short exposure time to the rapidly advancing isotope bolus and is therefore responsible only for the modest Mg absorption observed during the ...
Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis Santosh R. Alluri, Yusuke Higashi, Ashley Berendzen, Laurel A. Grisanti, Lisa D. Watkinson, Kamlendra Singh, Timothy J. Hof...
Human interleukin-22 (IL-22) is known as a “dual function” cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens. On the other hand, the ov
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The sections were incubated with rabbit anti-phospholipase A2 (Pla2g2a) and gold-labeled goat anti-rabbit Ig. Bar = 1 μm. E–G, EM immunohistochemical demonstration of cryptdin accumulation in the secretory granules of intermediate cells located in the lower and middle thirds of the crypt (...
This ∼1-kb DNA fragment was purified, labeled with [α-32P]dCTP (Amersham Pharmacia Biotech) using a random oligonucleotide-priming labeling kit (Amersham Pharmacia Biotech), and used as a probe. Hybridization and washing conditions were as recommended by CLONTECH. In these conditions, y+LAT-...