of the crypt to the villus tip. These blue ribbons persisted in the intestine of the mice for more than 300 days and encompassed all the intestinalcell lineages, thus showing thatLgr5+have long-term self-renewal and multipotent differentiation capacity both in the small andlarge intestine. ...
THE SMALL INTESTINE The small intestine, which is approximately 6 m long, begins at the pylorus and joins the large intestine at the ileocaecal valve. Its main function is the digestion and absorption of foodstuffs. The presence of folds, villi and microvilli vastly increases the surface ...
ARTICLES nature publishing group The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct SA Houston1, V Cerovic1, C Thomson1, J Brewer1, AM Mowat1 and S Milling1 Dendritic cells (DCs) in the small intestine (SI) and colon are fundamental ...
38,39. While extensive analyses ofC. elegansArgonautes, small RNAs, and pathways have been carried out, relatively little is known regarding the conservation, divergence, or function of these pathways in other nematodes8,40,41. Nematodes have been divided into three major classes and ...
MicroRNA (miRNA) delivery by extracellular vesicles (EVs) has recently inspired tremendous developments in cancer treatments. However, hybridization between miRNA and its target mRNA is still difficult to be imaged in vivo to assess the therapeutic effec
The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, an
Schematic diagram of part of the human gastrointestinal tract, shown as a not-at-scale stretched rendering. The duodenum (3), jejunum (4), and ileum (5) (all schematically shown) form the small intestine after the stomach (2) and esophagus (1). The large intestine comprises the colon (...
Plate 1.12 The eye and accessory ocular structures. Plate 1.13 The nose. Plate 1.14 The ear. Plate 1.15 Mouth and tongue and esophagus. Plate 1.16 Ventral view of the abdomen and its structures. Plate 1.17 Large intestine, anus and anal sacs. Plate 1.18 Body cavities and serous membranes. ...
The uptake of many lipids from circulation by mammary cells has been demonstrated in labeled animal studies, where lipoprotein lipase presence allows uptake of fatty acids, cholesterol, and phosphatidylcholine in rats [64]. While this has not been demonstrated in humans, lipase increases dramatically ...
novel therapeutic approaches are urgently needed. In this regard, siRNAs hold great promise, mainly due to the ability to specifically target disease genes and due to the flexibility in modulating a large range of targets. However, because of challenges in stability and delivery, it may take time...