Signal transduction of bone morphogenetic protein receptors Anja Nohe, ... Nils O. Petersen, in Cellular Signalling, 2004 Smad proteins can be divided into three distinct classes: the receptor-activated Smads (R-Smads), the common-mediator Smads (Co-Smads) and the inhibitory Smads (I-Smads)....
Small mothers against decapentaplegic (SMAD) proteins are a family of signal transduction molecules in transforming growth factor β (TGFβ) ligand pathways that have been found to have a key role in the pathogenesis of inflammatory bowel disease (IBD).
【Key words】Osteoporosis TGF-β Smad protein Signal transduction iteral 骨质疏松(Osteoporosis, OP)是一种骨量减低、骨组织显微结构退化,导致骨脆性增加、骨折危险性增高的全身性疾病。随着我国进入老年化社会,绝经后OP(Ⅰ型)和老年性OP(Ⅱ型)已成为威胁人类健康的社会问题。Ⅰ型主要是雌激素缺乏致骨吸收增加,Ⅱ...
Co-SmadandI-Smad.Smad2andSmad3belongtoR-Smad.ThepresentpaperexploreddifferentrolesofSmad2andSmad3inTGF-β1signaltransductioninmanyaspectssuchasstructure,functionandrelatedprotein.Keywords:Smad;Smad2;Smad3;transforminggrowthfactor-β1基(以甘氨酸和丝氨酸为基础)称为GAG;大的片段有30个氨基酸,在Smad2外显子3上,...
In addition, more recent evidence indicates that Smads can also function both as substrates and adaptors for ubiquitin protein ligases, which mediate the targeted destruction of intracellular proteins. Smads have thus emerged as multifunctional transmitters of TGF-β family signals that play critical ...
TGF-beta / Smad signaling pathway inhibitor (TGF-beta / Smad) Nine species SMAD have been found in protein family, called SMAD1-9,which were all found involved in TGF-BETA signal transduction. They a
宿主Rabbit反应种属Human, Mouse, Rat 克隆类型rabbit polyclonal抗原SMAD4 编 号包装库存目录价(￥)您的价格(￥)数量 D120124-002525 ul现货500500 D120124-0100100 ul现货16001600 D120124-0200200 ul现货25002500 产品描述 概述 This gene encodes a member of the Smad family of signal transduction proteins. ...
However, autophagy pathways may also select specific cargoes for degradation, for example damaged mitochondria, bacteria or protein aggregates4. Notably, termination of cytosolic signalling events by selective autophagy (signalphagy) is emerging as an important modulator of cell fate, although this has ...
Calcium-Calmodulin-dependent Protein Kinase (CaMK) Differentiation Signal Transduction Introduction Differentiation of mesenchymal stem cells toward the osteogenic lineage is a collaborative/synergistic process involving a combination of several intracellular signaling pathways triggered by the extracellular matrix (...
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