www.nature.com/scientificreports OPEN Crystal structure and SUMO binding of Slx1-Slx4 complex received: 15 September 2015 accepted: 11 December 2015 Published: 20 January 2016 Fu-Ming Lian, Si Xie & Chengmin Qian The SLX1-SLX4 complex is a structure-specific endonuclease that cleaves ...
The SLX1-SLX4 complex is a structure-specific endonuclease that cleaves branched DNA structures and plays significant roles in DNA recombination and repair in eukaryotic cells. The heterodimeric interaction between SLX1 and SLX4 is essential for the endonuclease activity of SLX1. Here, we present ...
Evolutionarily conserved structure-selective endonuclease MUS81 forms a complex with EME1 and further associates with another endonuclease SLX4-SLX1 to form a four-subunit complex of MUS81-EME1-SLX4-SLX1, coordinating distinctive biochemical activities of both endonucleases in DNA repair. Viral protein...