Slit-Robo pathwayOncogeneTumor suppressorGastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancer-related deaths. Due to the high frequency of metastasis, it is still one of the most lethal malignancies in which kinds of signaling pathways are ...
狭窄率及直径狭窄率均降低(P <0.05).结论:兔血管再狭窄模型 Slit2/Robo1的表达显著增高,R5抗体可有效抑制 Slit2/Robo1的表达,下调Slit2/Robo1信号通路可治疗兔血管成形术后再狭窄.%Objective To study the effect and mechanism of down-regulating Silt2/Robo 1 signaling pathway on rabbit iliac artery ...
Slit/Robo GTPase激活蛋白5) Signal pathway 信号通路 1. Wnt signal pathway and tooth development; Wnt信号通路与牙胚发育 2. Transforming growth factor-beta-Smad signal pathway in the development of palate; 转化生长因子-β-Smad信号通路在腭发育中的作用 3. Study on the signal pathway of cell ...
Signal Transduction in the Slit-Robo Pathway 211 Figure 2. Expression of srGAPs and Interaction between Endogenous srGAP1 and Robo1 (A) Northern blot analyses. Molecular weight markers are indicated on the left in kb. (B) Western blot analyses of srGAP1 were carried out using polyclonal anti...
The SLIT/ROBO pathway is classically known for its role in axon guidance, and is frequently lost in pancreatic cancer, but the biology behind this is poorly understood. Two recent articles (Nat. Commun. 2018;9:5082; Nat. Commun. 2018;9:5083) using mouse models show that SLIT/ROBO signalin...
Martinot and Boerboom Cell Commun Signal https://doi.org/10.1186/s12964-020-00696-6 (2021) 19:8 RESEARCH Open Access Slit/Robo signaling regulates Leydig cell steroidogenesis Emmanuelle Martinot and Derek Boerboom* Abstract Background: First identified as a regulator of ...
Role of the SLIT-ROBO signaling pathway in renal pathophysiology and various renal diseases SLIT ligand and its receptor ROBO were initially recognized for their role in axon guidance in central nervous system development. In recent years, as rese... L Feng,HP Shu,LL Sun,... - 《Frontiers ...
Slit2, a secreted protein, interacts with its receptor Robo1 to regulate the differentiation of intestinal stem cells and participate in inflammation and tumor development. However, whether Slit2/Robo1involved in the pathogenesis of UC is not known. We investigated Slit2/Robo1-mediated UC using ...
关键词中枢神经系统;细胞信号转导;Slit/RoboGTPase激活蛋白 Recent-desinSlit/RoboGTPasPActivatingProteinsSignal PathwayintheCentralNervousSystem ChaoZhang,Teng?FeiWang,Shan-ShanZhang,Yong'ZheChe MedicalCollegeofNankcdUniversity,乃anjin300071,China Al~WaetSlitproteinsinthecentralnervoussysternfCNS)Canbindtotheir...
4 reagents referenced in Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line.