SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. J. Mol. Cell. Cardiol. 2013; 64:124-131. [PubMed: 24090675]Jonathan D. Paul, Kareen L. K. Coulombe, et al. SLIT3-RO- BO4 activation promotes vascular network formation in ...
in vivo3. We also delineated that heparan sulfate, a type of highly sulfated polysaccharide and a member of the glycosaminoglycan family, binds Slit3 and functions as a co-receptor to facilitate the angiogenic Slit3-Robo4 signaling in developing diaphragm11. It is unknown if soluble Robo4 modul...
ROBO4 siRNA significantly attenuated the delayed corneal epithelial injury repair and nerve regeneration induced by SLIT3 treatment and ERS. Conclusions : ER stress inhibits corneal epithelial injury repair and nerve regeneration maybe related with the activation of SLIT3-ROBO4 pathway.Yang Lingling...
Research expression of Slit3 and Robo4 in corneal neovascularization of rats肖诗艺王莉陈仁典
CNV models were measured by biomicroscopy photography.Immunohistochemical staining and imaging analysis system were used to detect the expression of Slit3 and Robo4 in the models after 1,4,7,10 and 14 d. RESULTS: The area of CNV and the expression of Slit3,Robo4 were increased in CNV ...
《Slit3/Robo4调控integrinα5β1介导的脉络膜血管新生定向侵袭机制研究》是依托上海交通大学，由王雯秋担任项目负责人的青年科学基金项目。项目摘要 脉络膜新生血管（CNV）的定向侵袭机制复杂且少有报道。课题组前期研究发现integrinα5β1能独立于VEGF/VEGFR通路之外，单独或协同VEGF/VEGFR通路...