既往通过4个CRAB症状来诊断多发性骨髓瘤。最近研究表明,通过实验室检查和影像学检查发现了以特殊生物标志物为特征的多发性骨髓瘤的证据。这些生物标记物概括为SLiM,出现在CRAB症状之前。 • 对这些生物标记物进行测试,可使医生更早地诊断和治疗多发性骨髓瘤...
From criteria to clinic: How updated SLiM CRAB criteria influence multiple myeloma diagnostic activity.doi:10.1200/JCO.2024.42.16_suppl.7556983227556#Background:Multiple myeloma (MM) is a plasma cell malignancy, which is preceded by asymptomatic, precursor state of monoclonal gammopathy of ...
多发性骨髓瘤典型表现常称为CRAB和SLiM,CRAB指患者血钙增高、肾功能损害、贫血和溶骨性破坏。SLiM指患者骨髓中单克隆浆细胞比例≥60%,受累/非受累血清游离轻链比≥100、核磁共振检测有>1处5mm以上局部骨质破坏。 《中国多发性骨髓瘤诊治指南(2022年修订)》指出多发性骨髓瘤患者如有CRAB或SLiM表现需要启动治疗[1]。
SLiM CRAB Criteria Revisited: Progression Patterns in Patients with Smoldering Multiple Myeloma Matching the Criteria of 'Biomarker-Defined Early Multiple ... The control of diffusion in solids plays a significant role in diverse fields due to a wide range of applications in surface hardening, nuclear...
增加3个超高危生物标志物,作为活动性骨髓瘤的指标,与传统CRAB合并形成“SLiM-CRAB“诊断标准。 I中国多发性骨髓瘤诊治指南2017修订版诊断标准 新加入“肌酐清除率”以更好地评估肾功能。新加入“骨损”检测技术;继2014 IMWG诊断标准更新后,2015年中国指南也首次新增“SLiM”诊断标准。
Light-chain amyloidosis with concomitant symptomatic myeloma (CRAB-SLiM features): clinical characteristics, cytogenetic abnormalities, and outcomesPLASMA cell diseasesIMMUNOELECTRON microscopyMULTIPLE myelomaPROGNOSISOVERALL survivalCARDIAC amyloidosisBackground: Patients with light-chain (AL) amyloidosis and ...
P-155 Comparative analysis of outcomes in patients with CRAB versus SLiM criteria at diagnosis of multiple myelomadoi:10.1016/S2152-2650(23)01773-1Benjamin PatrickFarid AzadianHyra S. SapruChristopher CipkarHira MianArleigh McCurdyAlissa Visram