CRAB features C – hypercalcaemia R – renal insufficiency A – anaemia B – bone disease For the Primer, visit doi:10.1038/nrdp.2017.46 MANAGEMENT In general, treatment of multiple myeloma is commenced when patients show signs of end-organ damage (CRAB features). Several factors influence the...
The diagnostic criteria for active MM include presence of 鈮 1 CRAB features (hypercalcemia, renal failure, anemia, or one or more osteolytic bone lesions on skeletal radiology, CT or PET/CT imaging) in addition to clonal plasma cells on bone marrow. In 2014, the International Myeloma Working...
Background: Current prognostic scoring systems in multiple myeloma lack consensus and are often clinically impractical. The key diagnostic features known as CRAB; hypercalcaemia (C), renal impairment (R), anaemia (A), and bone lesions (B), are known to represent end organ damage i...
Multiple myelomaSLiMCRABPrognosisLIGHT-CHAIN RATIOFEATURESMultiple myeloma (MM) is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. Interphase fluorescence in situ hybridization (I-FISH) required for revised international staging system (R-ISS...
CARDIAC amyloidosisBackground: Patients with light-chain (AL) amyloidosis and concomitant multiple myeloma (MM) are known to have a worse prognosis, while the prognostic implication of cytogenetic abnormalities (CA) and optimal treatment schemes are not well-established. By comparing patients with MM ...
we report a 54-year old female who was hospitalized for intermittent and recurrent mild oral mucosal hemorrhage without other bleeding symptoms for almost one month or typical myeloma features.CASE SUMMARY Two months before admission,the patient underwent implantation of a permanent pacemaker due to ...