ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and down...
昆明地区中小学学生的 5-HT 转运体蛋白基因(SLC6A4)与儿童品行 障碍的关联性 Journal of Kunming Medical University / Kunming Yike Daxue Xuebao林雁张京晶黄高贵张翼宇芮溧姚树祥
Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects of SLC6A4 ...
Serotonin (5-HT) transporter (SLC6A4; SERT)Mouse studies suggest that a selective serotonin reuptake inhibitor (SSRI) could help treat cognitive impairment associated with Down syndrome.Nature Publishing Group USScience-Business eXchangedoi:10.1038/scibx.2010.835None...
Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles ofSLC6A4methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects ofSLC6A4...
Nineteen drug-free depressed psychiatric inpatients (nine suicide attempters) and nine neurological control subjects underwent lumbar puncture and psychiatric evaluation. CSF and plasma concentrations of AVP, serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and cortisol ...
Serotonin (5-HT) transporter (SLC6A4; SERT)Mouse and human studies suggest selective serotonin reuptake inhibitors (SSRIs) could help prevent AD.Science-Business eXchangedoi:10.1038/scibx.2014.717
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and ...
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which h...
在涉及基因型与药物部分分别增加了CYP2B6,5-羟色胺转运体SLC6A4,5-羟色胺2A受体HTR2A以及5-羟色胺与去甲肾上腺素再摄取抑制剂(SNRIs),类SSRIs活性的5-羟色胺(5-HT)调节剂相关内容,并更新了基于基因多态性的5-HT再摄取抑制剂类药物应用建议.本文对该指南相关内容进行解读,以期为我国5-HT再摄取抑...