目的分析S期激酶相关蛋白1(SKP1)和S期激酶相关蛋白2(SKP2)表达水平对肾透明细胞癌、肾嫌色细胞癌、肾乳头状细胞癌这3种肾癌患者预后的预测作用。方法使用TCGA数据库中肾透明细胞癌、肾嫌色细胞癌、肾乳头状细胞癌样本进行SKP1和SKP2表达水平及其甲基化与预后相关性分析、不同表达水平间基因突变情况分析。采用Metascape...
目的分析S期激酶相关蛋白1(SKP1)和S期激酶相关蛋白2(SKP2)表达水平对肾透明细胞癌,肾嫌色细胞癌,肾乳头状细胞癌这3种肾癌患者预后的预测作用.方法使用TCGA数据库中肾透明细胞癌,肾嫌色细胞癌,肾乳头状细胞癌样本进行SKP1和SKP2表达水平及其甲基化与预后相关性分析,不同表达水平间基因突变情况分析.采用Metascape数据...
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The elucidation of the Skp2 structure complexed with its cofactor Cks1 and bound to a phosphopeptide corresponding to the phosphodegron of the SCFSkp2 substrate p27Kip1 (Hao et al. [2005], this issue of Molecular Cell) resolves several key structure-function issues but, intriguingly, raises a...
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its...
SKPinC1,Skp2Inhibitor 的详细介绍 Product Information Molecular Weight: 465.34 Formula: C18H13BrN2O4S2 Purity: ≥98% CAS#: 432001-69-9 Solubility: DMSO up to 10 mM Chemical Name: (Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic...
Among 10 putative activators identified in this screen wasskr-1/2, highly conserved homologs of yeast and mammalian Skp1, which function to assemble protein complexes. Silencing ofskr-1/2inhibits induction of SKN-1 dependent detoxification genes and reduces resistance to pro-oxidants without ...
西安SKP的体验评价,怎么样、好不好?第1次来西安skp,只在负1层和1,2楼逛了一下,1楼主要是化妆品和和一些国际大牌,印象比较深的是售货员小姐姐和小哥哥都长得好好看哦[偷笑]
SKP2 activates ERα ubiquitylation and proteolysis. Putative late ERα targets were identified by expression profiling. SKP2 knockdown attenuated E2F-1 and BLM induction. SKP2 overexpression, but not coactivator motif mutant SKP2-L248QTAA252, enhanced estrogen-induced E2F-1 and BLM expression. SKP...
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