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We report here that the IκBα-ubiquitin ligase (IκBα-E3) is an SCF-like complex containing Skp1, cullin-1, and two homologous F-box/WD40-repeat proteins, βTrCP1 and βTrCP2. Intriguingly, all these components are cooperatively recruited to bind to a phosphorylated IκBα (pIκBα...
It is widely accepted that an F-box protein directs substrate ubiquitination within a Skp1·CUL1·F-box protein·ROC1 (SCF-ROC1) E3 ubiquitin ligase complex. This assembly utilizes the CUL1 molecular scaffold, allowing the F-box protein to position its bound substrate for ubiquitination by a ...