开发针对泛素-蛋白酶体机制核心成分的募集剂,例如针对对细胞活力至关重要的CUL1-CUL7 E3连接酶中的Cullin-RING E3连接酶复合接头蛋白(如DDB1、SKP1 或ELOB/ELOC)的募集剂,可以避免PROTAC可能产生的潜在未来耐药机制。 加州大学伯克利分校Nomura课题组研究...
Here we show thatPlasmodium bergheiexpresses a conserved SKP1/Cullin1/FBXO1 (SCFFBXO1) complex showing tightly regulated expression and localisation across multiple developmental stages. It is key to cell division for nuclear segregation during schizogony and centrosome partitioning during micro...
Cullin-associated and neddylation-dissociated protein 1 (CAND1) is a critical regulator of CRLs. It can modulate the formation rate of substrate receptor complex e.g. S-phase kinase-associated protein 1 (Skp1)-Cullin1-F-box protein (SCF), and then control the degradation rate of substrate p...
The most intensively studied cullin is metazoan CUL1 and its budding yeast ortholog Cdc53. CUL1 and Cdc53-based CRLs are called SCF complexes, and contain four subunits:Skp1;CUL1 (Cdc53); anF-box protein; and the RING H2 finger protein Rbx1/Roc1/Hrt1 [7]. The crystal structure of the ...
cullin1表达上调可能促进结直肠癌的发生,发展,转移并且影响预后. 关键词: cullin1; 结直肠癌; 预后 abstract objective to study the expression and clinical significance of cullin1 in colorectal cancer. methods immunohistochemistry (ihc) was used to detect cullin1 protein expression level in 121 cases of...
属第一医院口腔科主任、口腔教研室主任，学科带头人，预防保健体检中心主任。 长期从事口腔医学专业实践，在颅颌面部重点对疑难重症的综合诊治领域开展了多项 技术创新与探索。对头颈颌面部重症疑难病症的诊治实践积累了丰富的临床经验和娴熟的 诊疗操作技术，尤其擅长口腔颌面部较大组织缺损的修复重建和颌面-颅底及颌...
Although several positive regulators of SSC self-renewal have been discovered, little is known about the negative regulators. Here, we report that F-box and WD-40 domain protein 7 (FBXW7), a component of the Skp1-Cullin-F-box–type ubiquitin ligase, is a negative......
Cullin-1和Skp2在鼻咽癌及癌前病变组织中的表达
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Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle progression, development, and survival. Cul1 ...