Proteomic analysis of co-immunoprecipitates showed that wild-type cells able to fully glycosylate Skp1 had a greater abundance of an SCF complex containing the cullin-1 homolog CulE and FbxD, a newly described WD40-type F-box protein, than the complexes that predominate in cells defective in...
SCF复合物由Skp1、Cullin 1及含有F-盒结构的泛素E3连接酶组成,Cullin 1、E3连接酶在多种肿瘤中发生异常,并已成为肿瘤治疗的靶标。但是,作为连接Cullin 1和E3连接酶接头蛋白的Skp1在肿瘤中是否发生异常、是否参与肿瘤的发生及能否成为肿瘤治疗的药物靶标,一直未见报道。 为了解Skp1在肺癌发生发展中的作用,中国科学...
开发针对泛素-蛋白酶体机制核心成分的募集剂,例如针对对细胞活力至关重要的CUL1-CUL7 E3连接酶中的Cullin-RING E3连接酶复合接头蛋白(如DDB1、SKP1 或ELOB/ELOC)的募集剂,可以避免PROTAC可能产生的潜在未来耐药机制。 加州大学伯克利分校Nomura课题组研究...
SKP2 (S-phase kinase associated protein 2) 该基因编码一个蛋白家族成员,其特征是约有40个氨基酸基序,即二聚体。f-box蛋白是泛素蛋白连接酶复合物scfs(skp1-cullin-f-box)的四个亚基之一,在磷酸化依赖性泛素化中发挥作用。f-box蛋白分为3类:含wd-40结构域的fbws、含富含亮氨酸重复序列的fbls和含不同蛋白...
Fig. 1.Illustrated pathways of Skp2-mediated degradation of its major downstream targets. The SCF (Skp1-Cullin 1-F-box) complex consists of four components: the invariable component Skp1 (Adaptor protein), Rbx1 (RING finger protein) and Cullin1 (Scaffold protein), and the interchangeable F-...
S期激酶相关蛋白1(S-phase kinase-associated protein 1,SKP1)作为SCF(Skp1-Cul1-F-box)复合体的接头蛋白,分别连接Cullin-1(Cul1)和F-box蛋白.该家族蛋白参与植物生长发育的调控,并响应生物/非生物胁迫逆境.为揭示该家族成员在小麦(Triticum aestivum)这一重要农作物中的基本生物学特性和功能,本研究自小麦中鉴定...
S phase kinase-associated protein 1 (Skp1)-Cullin1-F-Box protein (SCF) complexes are the best characterized among CRLs, which play crucial roles in numerous cellular processes and physiological dysfunctions, such as in cancer biology. Currently, there is growing interest in developing SCF-...
Gene SummaryThis gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regula...
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitin...
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitin...