It is characterized by abnormalities in skeletal muscle structure and function, including muscle atrophy, a shift from type I to type II fibers, metabolic dysfunction, impaired excitation-contraction coupling, and decreased muscle contractility which, in combination, play a major role in shortness of...
The objective of this review is to provide a systems-level, comprehensive mapping the molecular mechanisms underlying skeletal muscle structure and function, in health and disease. We begin this review with a focus on molecular mechanisms underlying muscle tissue development (myogenesis), with an ...
This chapter investigates the structure and organization of skeletal muscle at an intermediate level, serving as a bridge between Chaps. 1 and 2. Hence, learn about the hierarchical matrix of skeletal muscle design or individual parts leading to a better appreciation of the composite structure of...
41 studies performed between 1985 and 2015 reported that the use ofNSAIDsis more effective in the treatment of lower body muscle injuries when compared with upper body injuries. Additionally, after a short-term acute muscle injury, NSAIDs reduced pain, bloodcreatine kinaselevel, and strength loss...
Complex systems biology approach to understanding coordination of JAK-STAT signaling. In this work, we search for coordination as an organizing principle in a complex signaling system using a multilevel hierarchical paradigm. The objective i... RP Soebiyanto,SN Sreenath,CK Qu,... - 《Bio System...
activity2. Aging results in a gradual loss of muscle function, which varies based on sex and the level of muscle activity3. The accelerated loss of muscle mass and function, associated with increased adverse outcomes including falls and frailty, results in sarcopenia4(also called muscle wasting)...
W514R is one such mutation in the Ig fold which leads to severe phenotypes in Skeletal Muscle Dystrophy (SMD) which is a class of laminopathies. In this report, we elucidated gross alterations in structure and dynamics at the level of individual amino acids. These studies indicate altered ...
Neurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regeneration. Although several in vitro studies have investigated how motor neurons and endothelial cells interact with skeletal myocytes
The entire muscle organization is held together by a distinct hierarchy of extracellular matrix (ECM), which facilities muscle structure and force transmission. This hierarchal organization (starting at the muscle fiber level; depicted in Fig. 21.1) entails an endomysium around each individual fiber,...
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyS. L. Lindstedt, T. McGlothlin, E. Percy, and J. Pifer, "Task-specific design of skeletal muscle: Balancing muscle structural composition", Comp. Biochem. Physiol. , vol. 120, no. 1, pp....