Thus, it is important to integrate different levels of data, including both mRNA and DNA level regulation, to better understand these adaptive changes. In this study, our goal was to define the adaptive changes in the skeletal muscle of patients with Type 2 diabetes after 16 weeks of aerobic...
We previously reported cross-sectional associations of skeletal muscle oxidative capacity with PET imaging markers of amyloid in the brain9 and longitudinal brain atrophy with dual decline in memory and gait related to mitochondrial dysfunction13,14. The associations were found in several brain regions ...
Skeletal Muscle Function is Based on Architecture The eminent surgeon Paul Brand basically got the design story about muscles right. He astutely observed that the architecture, or the orientation of muscle fibers within a muscle—not its mass or volume—determined its function.1 The take-home lesso...
(2009). Skeletal muscle as a paradigm for regenerative biology and medicine. Regen. Med. 4, 293-319.Gayraud-Morel B, Chretien F, Tajbakhsh S. Skeletal muscle as a paradigm for regenerative biology and medicine. Regen Med 2009;4:293-319....
The musculoskeletal system, containing bones, cartilage, skeletal muscles, tendons, ligaments, and some other tissues, is a perfect system that undergoes the external and internal load properly and controls the body’s motion efficiently. In this system, skeletal muscle is obviously indispensable. Peop...
Type 2 diabetes mellitus (T2DM) is associated with reduced mitochondrial function in the skeletal muscle and metabolic inflexibility Healthy mitochondria require a tight balance between mitochondrial biogenesis and mitophagy, as well as between mitochondrial ATP and reactive oxygen species production Exercise...
In our study, the expression level of musclin mRNA in skeletal muscle was more than 15-fold higher than in bones of 10–12-week-old mice (Fig. 2B) and more than 10-fold higher than in bones of 6-week-old rats (data not shown). * This work was supported in part by the Suzuken...
The present study asks if this is a direct effect of increased glucose uptake by skeletal muscle. Incubation of primary human skeletal muscle cells (HSKMCs) with apoA-I increased insulin-dependent and insulin–independent glucose uptake in a time- and concentration-dependent manner. The increased ...
CXCL9, two of the candidate systemic cytokines identified using this pre-clinical model, are indeed detected at significantly higher levels in serum of COPD patients, and that their serum protein level is inversely correlated with the expression of aerobic energy metabolism genes in skeletal muscle....
(Grassi et al.1991; Kayani et al.2008). Others have also shown no correlation between physical activity and the maintenance of muscle mass (Mitchell et al.2003) and only a higher level of physical activity and not ‘leisure-time’ activity are able to prevent or delay some sarcopenic ...