Firstly, the muscle protein synthetic rate, which invariably rises when unlabeled amino acids are infused, did not increase in the group receiving pamidronate. Further- more, muscle protein breakdown was significantly lower in the pamidronate group than in the placebo group des- pite a large ...
Over the last 3 h, unlabeled amino acids are also infused. This provides additional substrate for muscle protein synthesis; normally, what is seen is a spike in synthetic rate. However, inevitably, muscle protein breakdown exceeds muscle protein synthesis.10 Both endogenous glucocorticoids and pro-...
the 5'-enhancer (-1,256 to -1,050) is the best characterized of the known regions [18,20,23–28]. It has the ability (1) to drive high-level transcription of reporter genes in skeletal and cardiac muscle in both transgenic mice ...
Regulation of muscle contraction by MyBP-C isoforms was determined using recombinant proteins representing the N-terminal region of slow-skeletal, fast-skeletal, and cardiac isoforms of MyBP-C. (A) Schematic diagram of full-length slow-skeletal, fast-skeletal, and cardiac MyBP-C isoforms (ssMyB...
Given the functionalsignificance of AChE in the nervous system, it thus becomes important toidentify the molecular and cellular mechanisms regulating its expression indeveloping tissues as well as in neurons and skeletal muscle cells placedunder a variety of conditions known to markedly affect AChE ...
OCTN2 (SLC22A5) is a carnitine transporter whose main function is the active transport of carnitine into cells. In skeletal muscle and other organs, the regulation of the SLC22A5 gene transcription has been shown to depend on the nuclear transcription fa