Firstly, the muscle protein synthetic rate, which invariably rises when unlabeled amino acids are infused, did not increase in the group receiving pamidronate. Further- more, muscle protein breakdown was significantly lower in the pamidronate group than in the placebo group des- pite a large ...
It has been previously reported that altered expression of CD44 in skeletal muscle of DMD patients63 as well as serum levels in cancer patients provides a measure of tissue damage.64 The Venn diagram in Figure 6H shows 5 genes with retained exon events in RH-hMuSC-1 upon treatment with CM...
Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood. Modulatory region 1 (MR1) is a 1-kb regulatory regi
Over the last 3 h, unlabeled amino acids are also infused. This provides additional substrate for muscle protein synthesis; normally, what is seen is a spike in synthetic rate. However, inevitably, muscle protein breakdown exceeds muscle protein synthesis.10 Both endogenous glucocorticoids and pro-...
Complete and detailed, this Skeletal System Coloring Workbook is perfect for instruction, study and even testing high school level students.
Within the proximal promoter are two A + T-rich motifs, mAT1 and mAT2, which greatly enhance muscle-specific transcription; myogenic cells contain proteins that bind to these sequences. MEF-2 binds to both mAT1 and mAT2; a mutation abolishing its binding to mAT1 greatly diminishes the ...
focus on heart muscle. Figure 1 Regulation of muscle contraction by MyBP-C isoforms was determined using recombinant proteins representing the N-terminal region of slow-skeletal, fast-skeletal, and cardiac isoforms of MyBP-C. (A) Schematic diagram of full-length slow-skeletal, fast-skeletal, ...
Given the functionalsignificance of AChE in the nervous system, it thus becomes important toidentify the molecular and cellular mechanisms regulating its expression indeveloping tissues as well as in neurons and skeletal muscle cells placedunder a variety of conditions known to markedly affect AChE ...
OCTN2 (SLC22A5) is a carnitine transporter whose main function is the active transport of carnitine into cells. In skeletal muscle and other organs, the regulation of the SLC22A5 gene transcription has been shown to depend on the nuclear transcription fa
PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle. Int. J. Mol. Sci. 2022, 23, 12304. https://doi.org/10.3390/ ijms232012304 Academic Editor: Amelia Casamassimi Received: 24 August 2022 Accepted: 5 October 2022...