The only open access journal in its field, Skeletal Muscle publishes novel, cutting-edge research and technological advancements that investigate the ...
The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study in
The purpose of this article is to describe the image findings of distant metastases to skeletal muscle with clinical correlation. The records of nine consecutive patients with biopsy-proven metastases to skeletal muscle from primary malignancies were retrospectively reviewed for clinical history and ...
To address this, recent mouse and human skeletal muscle studies pioneered the use of either single-cell RNA sequencing (scRNA-seq)12,13,14,15,16 or single-nucleus RNA sequencing (snRNA-seq)17,18,19,20,21 to understand muscle cell type heterogeneity and their changes in aging. However, both...
Full size image Fig. 3: Clock alterations resulted in changes among circadian properties and differential expression in mouse skeletal muscle. aScatter plot depicts the overall distribution of ~24 h genes of interest in WT andClockmutantmice.bAcrophase bin plot depicts the distribution of phases ...
Download:Download full-size image Figure S1. Muscle-Specific PGC-1α1 Transgene Expression, Related toFigure 1 (A and B) Measurement of parameters for locomotor activity during the novel cage test (n = 5). (C) Sucrose preference of the indicated groups (n = 7). ...
3D). In addition, EDL muscle twitch:tetanus ratio was significantly higher in MLC-Cre:GRK2fl/fl compared with GRK2fl/fl mice (0.3 ± 0.004 and 0.26 ± 0.01, respectively), whereas no difference was detected between groups in the soleus (Fig. 3E). Download: Download high-res image (187...
摘要: Purpose To obtain high‐resolution Cr and PCr maps of mouse skeletal muscle using a polynomial and Lorentzian line﹕hape fitting (PLOF) CEST method. Methods Wild‐type mice and guani... 查看全部>>关键词: chemical exchange saturation transfer creatine guanidinoacetate guanidinoacetate N﹎...
Full size image Muscle biomechanical stiffness Since Col VI levels were higher inA.cahirinusand in view of the role that this molecule plays in regulating the stem cell niche via the muscle biomechanical properties22,23we next examined the physiological stiffness of freshly isolatedM.musculusandA.cahi...
Fig. 1: Ablation of IRF4 in skeletal muscle attenuates NASH. Full size image To investigate whether the ablation of IRF4 in skeletal muscles ameliorated NASH progression, we generated skeletal muscle-specific IRF4 knockout (F4MKO) mice, as previously described19. Male mice were then fed a Wes...