The size of the human proteome: the width and depth. Int J Anal Chem. 2016;7436849:2016.Ponomarenko EA, Poverennaya EV, Ilgisonis EV, Pyatnitskiy MA, Kopylov AT, Zgoda VG, Lisitsa AV, Archakov AI. The size of the human proteome: the width and depth. Int J Anal Chem. 2016;2016:...
This work discusses bioinformatics and experimental approaches to explore the human proteome, a constellation of proteins expressed in different tissues and organs. As the human proteome is not a sta...
We discuss the problems in defining the extent of the proteomes for completely sequenced eukaryotic organisms (i.e. the total number of protein-coding sequences), focusing on yeast, worm, fly and human. (i) Six years after completion of its genome sequence, the true size of the yeast prot...
To demonstrate the sensitivity of this analytical approach to detect physiological changes in exosome proteomic cargo, we evaluated the effects of acute exercise on proteome cargo of EVs isolated from human plasma samples. Results SEC improves plasma EV proteomics characterization SEC is a low-...
The size of cell of an organism has no relation with the size of the body. Do you agree with the above statement? Give reasons for your answer. Mitosis: Mitosis is a type of cell division in which two daughters cells ...
However, many cellular modulation and regulation aspects extend beyond nucleic acids and necessitate a focus on the proteome. Processes such as post-transcriptional control of protein translation, post-translational modifications, and protein degradation through proteolysis significantly influence cellular ...
High levels of Cks2 were observed in a broad range of human malignancies (Liberal et al., 2012). Interestingly, a recent report has shown that Cks2 is a short-lived protein (Eden et al., 2011), but its mechanism of degradation had not been identified. To examine whether Cks2 is ...
Of note, the AGS of complete prokaryotic genomes increases with the cumulative number of associated phages and other mobile genetic elements37. Similarly, AGS estimates derived from metagenomic sequences of uncultured “free-living” microbes (captured in 0.1–3 µm-size filters) may also be...
Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale Structural genomics requires the application of a standardised process for overexpression of soluble proteins that allows high-throughput purification and ... C Holz,B Prinz,N Bolotina,......
What is a genome in the perspective of genetics? How many DNA molecules are present in a human cell's nucleus? How many genomes are there in the United States of America? What length or height of human DNA during the cell division?