SITE-SPECIFIC ANTIBODY CONJUGATION METHODS AND COMPOSITIONSProvided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.ARATHOON William RobertPADAWER IshaiCANO Luis AntonioSISODIYA Vikram Natwarsinhji...
抗体-药物偶联物(Antibody-drug Conjugate)的概述 抗体-药物偶联物(简称ADC)是通过化学连接子与细胞毒性药物(称为有效载荷)连接的单克隆抗体组成的免疫偶联物(图1A),是用于治疗癌症的新型靶向药物。 利用细胞毒素与单克隆抗体靶向结合能力,ADCs可直接高效地...
Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences, which was enabled by the development of chemoselective reactions for the site﹕pecific modification of proteins. Antibody﹐ligonucleotide conjugates combine the antibody's target specificity with ...
Antibody-drug conjugates (ADCs) have become a promising class of antitumor agents with four conjugates being approved by regulatory agencies for treating cancer patients. To improve the conventional conjugations that are currently applied to generate these heterogeneous products, various site-specific approa...
With advances in the fields of bioorthogonal chemistry and protein engineering, there is growing interest in producing ADCs by site-specific conjugation to the antibody, yielding more homogeneous products that have demonstrated benefits over their heterogeneous counterparts in vivo. Here, we chronicle the...
Production of ADCs is an area where improvement is needed because current methods yield heterogeneous mixtures that may include 08 drug species per antibody molecule. Site-specific conjugation has been recently shown to eliminate heterogeneity, improve conjugate stability, and increase the therapeutic ...
Antibody-based diagnostic and therapeutic agents play a substantial role in medicine, especially in cancer management. A variety of chemical, genetic and enzymatic site–specific conjugation methods have been developed for equipping antibodies with effector molecules to generate homogeneous antibody conjugates...
Site-specific antibody-drug conjugates 专利内容由知识产权出版社提供 专利名称:Site-specific antibody-drug conjugates 发明人:Van Berkel, Patricius Hendrikus Cornelis,Howard, Philip Wilson 申请号:AU201624 7584 申请日:201604 15 公开号:AU201624 7584 A1 公开日:20171026 摘要:Site-specific antibody-drug ...
Simple, fast, and site-specific antibody labeling to oligos, enzymes, fluorescent proteins & dyes, drugs and more.
Junutula, J., Raab, H., Clark, S.et al.Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.Nat Biotechnol26, 925–932 (2008). https://doi.org/10.1038/nbt.1480 Download citation Received17 April 2008 ...