Chloride channel activity of CFTR is dependent on protein phosphorylation and presence of nucleoside triphosphates. From electrophysiological studies of CFTR detailed models of its regulation by phosphorylation and nucleotide interaction have evolved. These investigations provide ample evidence that ATP ...
Di¡erential function of the two nucleotide binding domains on cystic ¢brosis transmembrane conductance regulatorThe genetic disease cystic fibrosis is caused by defects in the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR). CFTR belongs t...
The extracellular matrix (ECM) is a vital acellular scaffold present in all tumor tissues, composed of various macromolecules such as collagen, elastin fibers (EF), fibronectin (FN), proteoglycans (POSTN) and glycoproteins (GP) [1,2]. It plays a critical role in creating microenvironments for ...
Evaluation of a SPLUNC1-derived peptide for the treatment of cystic flbrosis lung diseaseIn cystic fibrosis (CF) lungs, epithelial Na~+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection, and ...
mutation N 1325 S in cardiac sodium channel gene SCN 5 A causes cardiomyocyte apoptosis , cardiac fi brosis and contractile dysfunction in micea Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA b Center for Cardiovascular Genetics/NE40, Lerner ...
The holder at the anodic site remains in place to receive and align the sensor cell, which uses a conical collecting surface to channel the sweat directly and anaerobically from the sweat ducts to the continuous 炉ow-through conductivity cell within its body. A crib-side analysis unit ...
In control larvae grown in standard food, autophagosomes were barely detected, whereas autophagy induction by starvation led to the formation of acidic autolysosomes, which could be visualized only in the red channel, due to GFP quenching. In fed D-iduaRNAi3 larvae, we observed the formation of...