Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) replicative senescence with telomere attrition; and (2) stress-induced premature senescence without telomere involvement. Both types of ...
Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) replicative senescence with telomere attrition; and (2) stress-induced premature senescence without telomere involvement. Both types of ...
Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) replicative senescence with telomere attrition; and (2) stress-induced premature senescence without telomere involvement. Both types of ...
Sirtuins, Cell Senescence, and Vascular Aging 2016, Canadian Journal of Cardiology Citation Excerpt : Therefore, SIRT1 modulation could be a promising target to counteract vascular aging in humans. Currently, there are ongoing clinical trials on the efficacy of SIRT1 modulators, especially SIRT1 acti...
et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J. Immunol. 192, 958–968 (2014). Article CAS PubMed Google Scholar Xu, C. et al. SIRT1 is downregulated by autophagy...
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 18, 416–430 (2013). This study demonstrates that the mammalian NAD+-dependent deacetylase SIRT1 plays a crucial part in the regulation of mammalian ageing and ...
Sirtuins, Cell Senescence, and Vascular Aging The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT family members have been identified in mammals, from SIRT1,... Y Kida,MS Goligors...
Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 117(Pt 11):2417–2426
B Pathogenesis of IVDD, which mainly involves NP cell metabolism (senescence and apoptosis), inflammation, ECM degradation, and oxidative stress. C Role of SIRT in NP cell survival and activity.SIRT mainly activates autophagy, maintains intracellular homeostasis, and inhibits apoptosis Full size image...
level of cell cycle inhibitors, activity of senescence associated β-galactosidase, granularity and DNA damage. The elevation of DNA damage with age is the result of impaired efficiency of DNA repair systems. It is believed that DNA damage is the main cause of cellular senescence. It concerns bo...