quercetin; inflammation; oxidative stress; macrophage; redox; immunometabolism; SIRT1/PGC-1α signaling pathway1. Introduction The oxidation–reduction (redox) system plays an important role in maintaining cellular redox homeostasis and preventing oxidative damage to DNA, proteins and lipids caused by ...
PGC-1𝛼 in NIH/3T3. Meanwhile, the relative protein expression of SIRT1 was decreased in the model group compared with the GOPs-treated group. Given that SIRT1 needs NAD+to function, this result may be explained by the observation that NAD+depletion decreased SIRT1 consumption in the model...
3.6. Vigeo Attenuates Dex-Induced Muscle Atrophy through AMPK/Sirt-1/PGC1α and Akt/mTOR Signaling in C2C12 Myoblast Cells in Vitro Based on the in vivo experimental data showing that Vigeo has a positive effect on Dex-induced muscle atrophy, we examined whether the same tendency was observed...