These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly. Inhibition of mitochondrial fission may be a potential target for delaying ...
This study investigated whether Tilianin regulates mitochondrial energy metabolism and oxidative stress in MIRI via AMPK/SIRT1/PGC-1 alpha signaling pathway. The MIRI model was established by 30 min of coronary occlusion followed by 2 h of reperfusion in rats. The results revealed that Tilianin ...
Taken together, this study found that Tilianin could attenuate MIRI by improving mitochondrial energy metabolism and reducing oxidative stress via AMPK/SIRT1/PGC-1 alpha signaling pathway. 展开 关键词: AMPK Myocardial ischemia/reperfusion injury PGC-1α SIRT1 Tilianin ...
系统标签: neurochem ampk pgc ischemia oxidative neurons Thepromiseofepigenetictherapy:reprogrammingthecancerepigenomeAndrewDKellyandJean-PierreJIssaEpigeneticsreferstoheritablemoleculardeterminantsofphenotypeindependentofDNAsequence.EpigeneticfeaturesincludeDNAmethylation,histonemodifications,non-codingRNAs,andchromatinstruct...
ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway (2017). ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1alpha-Sirt3 pathway. Neurochem. Int. 108, 230-237... SG Liu,YM Wang,YJ Zhang...
quercetin;inflammation;oxidative stress;macrophage;redox;immunometabolism;SIRT1/PGC-1α signaling pathway 1. Introduction The oxidation–reduction (redox) system plays an important role in maintaining cellular redox homeostasis and preventing oxidative damage to DNA, proteins and lipids caused by free radica...
Pathogens 2022, 11(2), 116; https://doi.org/10.3390/pathogens11020116 ActionDateNotesLink article xml file uploaded 19 January 2022 14:47 CET Original file - article xml uploaded. 19 January 2022 14:47 CET Update https://www.mdpi.com/2076-0817/11/2/116/xml article pdf uploaded. 19 Jan...