The expression of SIRT1, PGC-1伪, Bcl-2 mRNA level and translation level, and the expression of Nrf2 mRNA level were also significantly increased at each dose, while the expression of Caspase-3mRNA level and translation level were significantly decreased,...
目的:探讨芍药苷(PF)调节沉默信息调节因子 2 同系物 1(SIRT1)/氧化物酶体增殖物激活受体γ共激活剂-1α(PGC-1α)/核因子E2 相关因子2(Nrf2)信号通路对过氧化氢(H2O2)... 黄燕,杨艳清,周进飞 - 《河北医学》 被引量: 0发表: 2024年 黄芪甲苷通过调控Sirt1/PGC-1α信号通路发挥对阿霉素肾病的保护作用...
Nrf2 可调控 Sirt1 的表达,这在国际上尚未报道,在此基础上,我们提出的 Sirt1/PGC-1α 通路在 Nrf2-ARE 通路调控线粒体功能对糖尿病肾脏病足细胞的保护作用和机制的研究,更是尚未报道,本研究对将进一步揭示早期糖尿病肾脏病发病和进展的机制、突破抗肾素-血管紧张素系统的传统治疗策略,为糖尿病肾脏病的防治提供...
Taken together, these findings indicated that the important antioxidant role of ATR-I in MPTP/MPP + -mediated oxidative stress and the pathogenesis of PD through the SIRT1/PGC-1α/Nrf2 axis, highlighting its potential as a therapeutic option for PD. 展开 关键词: Atractylenolide-I Parkinson’s...
Calycosin-7-O-beta-D-glucoside attenuates OGD/R- induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1/FOXO1/PGC-1 alpha pathway in HT22 cells. Neural Plast. 2019;2019:8798069. Article PubMed PubMed Central Google Scholar Waldman M, Cohen K, Yadin D, et al...
Overexpression of GAS5 demonstrated protective effects against sepsis-induced renal injury via downregulating miR-579-3p and activating SIRT1/PGC-1alpha/Nrf2 pathway to inhibit cell pyroptosis. 展开 关键词: cell pyroptosis GAS5 miR-579-3p SIRT1 sepsis-associated renal injury ...
目的:探讨沉默信息调节因子1 (SIRT1)过表达介导PPARγ-PGC1α-NRF2通路对肥胖症大鼠肝脏脂肪沉积和变性及氧化应激的影响.方法:首先构建SIRT1慢病毒载体(LV),然后将大鼠随机分为4组:正常对照组(Contro1),肥胖症模型组(Obesity mode1组),肥胖症+SIRT1对照载体组(Obesity+LV组)和肥胖症+SIRT过表达组(Obesity+LV...
Moreover, treatment with the inhibitor EX527 showed that MRGD promoted mitochondrial biogenesis ability through the SIRT1/PGC-1α pathway and interfered with mitochondrial dynamics, and activate Nrf2. In summary, MRGD played a key role in promoting mitochondrial function and thus alleviating ...
SIRT1是哺乳动物sirtuins家族中的一员,是依赖烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide, NAD+)的去乙酰化酶 [ 8 ] ,参与多种生理功能的调节,不仅能去乙酰化组蛋白,还能作用于包括p53、过氧化物酶体增殖物激活受体γ共激活因子-1α(peroxisome proliferator-activated receptor γ coactivator-1α, PGC...
Nrf2: nuclear factor erythroid 2–related factor 2 PAI-1: plasminogen activator inhibitor-1 p66Shc: 66 kDa Src homology 2 domain–containing protein PGC-1α: peroxisome proliferator–activated receptor-γ coactivator 1α PKC: protein kinase C ...