Feldkamp U, Schroeder H, Niemeyer CM (2006) Design and evaluation of single-stranded DNA carrier molecules for DNA-directed assembly. J Biomol Struct Dyn 23: 657-666.Feldkamp U, Schroeder H, Niemeyer CM: Design and Evaluation of Single- Stranded DNA Carrier Molecules for DNA-Directed Assembly...
Hybridization efficiency of DNA-STV-conjugates depends on the position of the hybridization site in the carrier sequence, where the positions nearest to and farthest from the microarray surface proved to be most favorable. 展开 关键词: molecular dynamics HIV-1 integrase full-length structure ...
BirA also catalyzes the formation of biotin adenylate and the transfer of biotin from biotin adenylate to biotin carboxyl carrier protein. BirA and TraI36 share the antiparallel β sheet and helices that pack against it. The similarity, however, occurs with the BirA C-terminal biotin binding ...
A type of genetic carrier responsible for information storage and protein synthesis is DNA, a self-replicating molecule. In gene expression, the sequence of DNA gets transcribed into mRNA, later translated into an amino acid sequence. It is an essential process ...
Regulation of XPD Helicase by the Single-Stranded DNA Binding Protein RPA2AnimalsHumansGonadal Steroid HormonesGrowth HormoneReceptors, SomatotropinHomeostasisAgingCarrier ProteinsThe plasma high affinity growth hormone binding protein corresponds to the extracellular binding domain of the liver membrane receptor...
Serial samples of a long-term carrier showed relative stability of banding patterns over time. Epidemiologic analyses using this procedure showed banding patterns of case subjects to be identical to those of persons implicated as the source. This facile and discriminatory approach to the differentiation...
A single-nucleotide polymorphism (SNP) in a human gene can alter the behavior of the corresponding protein, and thereby affect an individual's response to drug therapy. Here, we describe a novel dual-targeting approach for introducing an SNP of choice in
This is accomplished by preceding the qPCR with a RT step that produces a double-stranded DNA copy of the RNA. RT-qPCR is a commonly used method to detect the genomes of human enteric viruses, as these typically consist of single-stranded RNA. Virus A small infectious agent th...
Single-stranded oligonucleotide therapeutics have evolved substantially since the use of DNA ASOs were first described in the late 1970s.4,5 The year 1998 saw the first ever approved ASO therapy, formivirsen, which consisted of a 21-mer DNA ASO with a phosphorothioate (PS) backbone (Figure 1...
In this experiment, the target nucleic acids were enriched by target capture prior to the double-stranded Splint-HEL workflow. The panel of capture probes was design to target the loci currently being used for Carrier Screening applications designed to detect recessive genetic disease alleles in pros...