Figure 7. Single-strand DNA-binding proteins of bacteria and eukaryotes. (a) Model of E. coli SSB tetramer-ssDNA complexes based on crystal structure information. SSB is a homotetramer of subunits (colored differently); each subunit has one OB fold. The SSB tetramer has two binding modes, ...
(1983) Inte- raction of single - strand binding protein and RecA protein at the single-stranded DNA site. J. Mol. Biol. 167:901-909.Cohen, S. P., J. Resnick, and R. Sussman. 1983. Interaction of single-strand binding protein and RecA protein at the single- stranded DNA site. J....
3National Center for Protein Science Shang- hai, 320 Yueyang Road, Shanghai 200031, China Human single-strand (ss) DNA binding proteins 1 and 2 (hSSB1 and 2) are components of the hSSB1/2-INTS3- C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maint...
Single-strand binding proteins bind to the two strands to prevent them from reannealing. ... Synthesizing ssDNA during DNA replication is important because it allows duplication of genetic material and thus the reproduction of cells. Another role of ssDNA is to aid with DNA repair.Single...
The accurate localization of proteins in fixed cells is important for many studies in cell biology, but good fixation is often antagonistic to good immunolabeling, given the density of well-preserved cells and the size of most labeled antibody probes. We therefore explored the use of single-stra...
The cloning and expression of two new human cDNAs encoding proteins highly related to the far upstream element-binding protein (FBP) are described. FBP, FBP2, and FBP3 comprise a family of single-strand DNA- binding proteins that possess all of the general features of more conventional transcri...
Thus, GBP is a new type of candidate telomere binding protein that binds, in vitro, to ss G-strand telomere DNA, the primer for telomerase, and has domains that have homology to RNA binding domains in other proteins. 展开 被引量: 84 ...
F. Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. J. Biol. Chem. 281, 13939–13948 (2006). Article CAS PubMed Google Scholar Rass, U., Ahel, I. & West, S. C. Defective DNA repair...
展开 关键词: Humans Guanine Diethyl Pyrocarbonate Cysteine Oligodeoxyribonucleotides Nerve Tissue Proteins RNA-Binding Proteins Molecular Probes Base Sequence Repetitive Sequences, Nucleic Acid DOI: 10.1074/jbc.270.48.28970 被引量: 170 年份: 1995 收藏...
We propose that these resected DSBs sequester both resection machinery and ssDNA binding proteins, which in wild-type cells would normally be recycled as Spo11-DSBs repair. The implication is that repair proteins are in limited supply, and this could reflect an underlying mechanism for regulating ...