Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. Howeve
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion in disease and therapy. However, it has been extremely challenging to analyze ...
Here, we present a single-cell multi-omic analysis of the immune response in refractory multiple myeloma patient tumors including profiling of CD8+ T cell antigen specificities. We also analyze changes in the T cell repertoire and gene... J Prazich - 《Journal of Immunology》 被引量: 0发表...
Single-cell immune repertoire analysisAuthor(s): Sergio E. Irac , Megan Sioe Fei Soon , Nicholas Borcherding , Zewen Kelvin Tuong Publication date (Electronic): April 18 2024 Journal: Nature Methods Publisher: Springer Science and Business Media LLC Read this article at ScienceOpenPublisher...
Immune Receptor Repertoire (AIRR) community was formed in 2015 to help address challenges related to AIR data analysis10,11,12. This has led to the standardization of repertoire data representation across AIR analysis domains. There are established packages that can deal with single-cell AIR ...
Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous... Y Alexander,N Daniel,S Ioana,... - 《Proceedings Biological Sciences》 被引量: 0发表: 0年 T-cell responses to HLA-A*0201 immunodom...
’s [63] study, mIHC analysis indicated that cytotoxic CD4+T cells potentially interact with HLA-II-expressing tumor cells. The cytotoxic T cells had the greatest clonal expansion, again indicative of a tumor-specific immune response. Notably, high PD-L1 expression on the tumor was not ...
The unbiased, paired analysis of T-cell receptor (TCR) α- and β-chain usage at the single-cell level provides a valuable window of understanding into the TCR repertoire and the nature of the immune response. Earlier technologies for TCR repertoire …more The unbiased, paired analysis of T...
We profiled 36,849 peripheral blood mononuclear cells from AD patients with amyloid-positive status and normal controls with amyloid-negative status by 5' single-cell transcriptome and immune repertoire sequencing using the cell ranger standard analysis procedure. We revealed five immune cell subsets: ...
Immune cell and V(D)J immune repertoire analysis Adaptive plasticity of tumor cells among transcriptional states is driven by signals from the TME4,14, which we investigated by generating a t-SNE plot of immune cells (Fig.4aand Supplementary Fig.7a) and performing hierarchical clustering of the...