2), remained stable over time in viremic animals and were undetectable in tight controllers (Supplementary Fig. 5). For animals in Groups 1, 2B, 3, and 4, which all received the same virus stock and challenge dose, the number of vDNA copies in lymphoid and GI tract tissues at necropsy...
We then examined the function of each gene module using GprofileR in an over-representation analysis across Gene Ontology biological processes. First, gene module D was enriched for pro-regenerative processes related to angiogenesis, EMT and wound repair, including blood vessel development, circulatory ...
To further understand the interaction between T cells and B cells in TLSs, we clustered the T-cell groups extracted from the original data. Twelve T-cell subtypes were identified (Fig. 6A), and each subtype was annotated based on marker gene expression (Fig. 6C). T-cell infiltration in ...
Last September, the continued advocacy of groups such as Bubble Home helped ensure that neurofibromatosis was included in China’s second catalog of rare diseases, signaling the government’s commitment to improving diagnosis, t...
Quantitative results of the histomorphometric analysis of the bone defects showed the new bone area at 8 weeks to be larger than that at 4 weeks in all groups. At 4 weeks, there were no significant differences between the two groups in terms of new bone area (p > 0.05). At 8 weeks,...
P values represent the overall comparison between the three groups using ANOVA. A P-value < 0.05 is statistically significant. d Spatial distribution of FXYD2, TonEBP/OREBP, and CLDN4; e Spatial image depicting the expression of GPX3 in the outer medulla. Scale bar: the white to red ...
The Con and Model groups received a similar volume of saline. On the 4th day after infection, all mice were weighed and blood was obtained via the orbital vein into saline to determine the lymphocyte type ratio. Lung and liver tissues were collected for inflammatory cytokine analysis, scRNA-...
Differentially expressed gene (DEG) analysis was conducted between fibroadenoma and normal epithelial cells using the FindMarkers and FindAllMarkers functions of the Seurat R package. The Wilcoxon rank-sum test (two-sided) was employed to identify DEGs between the two groups of epithelial cells. The...
We identified nine clusters in the integrated BE cell dataset with distinctive groups of DEGs (Supplementary Fig. 9d). Compared to BE cells in PCa tissue samples, significantly higher percentages of BE cells in organoids expressed KRT6A (organoid vs tissue, 77.4% vs 0.56%, P < 2.2e-...
Moreover, we further detected expression levels of the odontogenic gene between the CD24++ and CD24+ cell groups (Fig. 4h). We observed remarkably strong expression levels of odontogenic genes in the CD24++ cell group compared with the CD24+ group, such as Barx1, Bmp4, Lef1, Pax9, ...