Via single cell RNA sequencing, we find that CD39i increase the intratumor NK cells, conventional type 1 dendritic cells (cDC1) and CD8 + T cells and decrease the Treg abundance. The antitumor effect and reprog
Infected T cell clones are detected at low frequencies in the long-lived central memory compartment and overrepresented in the most differentiated memory subsets. Our results indicate that clonal expansions highly contribute to the persistence of the HIV reservoir and suggest that reservoir cells ...
Single-cell multiomics analysis reveals shared mutational signatures in both nonmalignant B cells and clonal T cells. The role of germ line ATM mutations in the pathogenesis of T-PLL should be further explored. Visual Abstract Download: Download high-res image (285KB) Download: Download full-...
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’ David S. Fischer, Meshal Ansari, Karolin I. Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H. Mayr, Maximilian Strunz, Niklas J. Lang, Elvira D’Ippolito, Monika...
Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression ArticleOpen access04 January 2023 Introduction Innate immune cells are abundant in the tumor microenvironment (TME) and play pivotal role in tumor progr...
Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinoma Article Open access 26 March 2025 Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations ...
Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma ArticleOpen access22 October 2024 Introduction Cervical cancer (CC) is one of the most prevalent gynecological tumors and the fourth leading cause of female cancer-rel...
et al. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat. Commun. 11, 4767 (2020). Article CAS PubMed PubMed Central Google Scholar Wu, X. et al. Single-cell sequencing of immune cells ...
For example, CAFs secrete WNT2 to promote cell proliferation and angiogenesis in CRC33,34. CAFs and preCAFs exhibit the greatest accessibility at the WNT2 TSS (Fig. 2b), suggesting that chromatin changes promote expression of WNT2 in CAFs and preCAFs. We also observed that preCAFs ...
then we established the subcutaneous tumor-bearing model by using murine lung cancer cell line 3LL to perform the anti-PD-L1 therapy and the single-cell RNA sequencing (scRNA-seq) to reveal the remodeling of TME. We confirmed that PD-L1 blockade significantly inhibited tumor progression in 3LL...