eQTLsingle 是一个独特而强大的工具,可以利用大量的 scRNA-seq 资源进行单细胞 eQTL 研究。 eQTLsingle has two modes. Cleaned-data mode: take input as SNV matrix and expression matrix from single cells. If you have had SNV and expression information of the same cell before, you can use this mod...
et al. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat. Genet. 53, 304–312 (2021). Article CAS PubMed PubMed Central Google Scholar Neavin, D. et al. Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in...
SCS【32】基于scRNA-seq数据中推断单细胞的eQTLs (eQTLsingle)https://mp.weixin.qq.com/s/TDqg6kfX0E64T21MVmaioQ关注桓峰基因公众号,获得更多学习资源!桓峰基因推出全新生信分析文字版和视频版免费教程,欢迎大家来围观,在公众号搜索即可获得相关教程!有测序,生信分
(2)任何表现出GWAS共定位和表达数量性状基因座(eQTL)信号的SNPs(FINEMAP/eCAVIAR共定位后验概率>0.01) (3)根据1000 Genomes数据集中欧洲血统个体的1期基因型计算的LD R2值≥0.8(有点绕:Any SNPs in LD with a SNP in the previous 2 categories based on an LD R2 value ≥0.8 calculated from phase 1 g...
Single-cell RNA-seqeQTL mappingUsing latent variables in gene expression data can help correct unobserved confounders and increase statistical power for expression quantitative trait Loci (eQTL) detection. The probabilistic estimation of expression residuals (PEER) and principal component analysis (PCA) ...
(DC), and COVID-19-associated variants had context and cell type-specific eQTL effects, with theIFNAR2variant (rs13050728) in particular having COVID-19-specific and monocytes-specific eQTL effect. In summary, our data linked innate immune cell dysfunction, especially ncMono, with severe CO...
Understand how to bring in data from single-cell RNA-seq experiments Quality control set-up 1. Exploring the example dataset 在本次研讨会上,我们将使用单细胞RNA-seq数据集,该数据集是Kang等人(2017年)进行的一项较大研究的一部分。在本文中,作者提出了一种利用遗传变异(eQTL)来确定基因的计算算法。 每...
[94]. Kang et al. utilized multiplexed droplet scRNA-seq to profile eight immune cell populations from 23 donors and subsequently conducted eQTL analysis, identifying 32 cis-eQTLs, 22 of which were cell-specific. Recently, Ding et al. constructed the first integrated human sceQTL database, ...
[94]. Kang et al. utilized multiplexed droplet scRNA-seq to profile eight immune cell populations from 23 donors and subsequently conducted eQTL analysis, identifying 32 cis-eQTLs, 22 of which were cell-specific. Recently, Ding et al. constructed the first integrated human sceQTL database, ...
singlecell_neuroseq_paperPublic template Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation optimising_singlecell_eqtl_paperPublic Repository containing the code to reproduce the analyses contained in our manuscript: Optimising expression quantitative trait locus mapping work...