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et al. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. eLife 10, e65857 (2021). Article CAS PubMed PubMed Central Google Scholar Cuomo, A. S. E. et al. Optimizing expression quantitative trait locus mapping workflows for single-cell studies. Genome Biol. 22...
Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells
Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease. Science. 2022;376:eabf3041. Article CAS PubMed Google Scholar Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, et al. Single-cell RNA-seq reveals cell type-specific molecular...
Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease. Science (New York, NY). 2022;376(6589):eabf3041. Article CAS Google Scholar Trynka G, Raychaudhuri S. Using chromatin marks to interpret and localize genetic associations to complex human traits and ...
Understand how to bring in data from single-cell RNA-seq experiments Quality control set-up 1. Exploring the example dataset 在本次研讨会上,我们将使用单细胞RNA-seq数据集,该数据集是Kang等人(2017年)进行的一项较大研究的一部分。在本文中,作者提出了一种利用遗传变异(eQTL)来确定基因的计算算法。 每...
Whole-organism eQTL mapping at cellular resolution with single-cell sequencingdoi:10.7554/elife.65857.sa2E. Ben-DavidJ. BoocockLonghua GuoS. ZdraljevicJ. BloomL. KruglyakCold Spring Harbor Laboratory
Scripts for "Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction"This repository also contains the code and data to recreate the figures, tables, performs trans-eQTL hotspot analysis, cell-cycle stage assignment, raw data processing, and additional links to generated...
singlecell_neuroseq_paperPublic template Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation optimising_singlecell_eqtl_paperPublic Repository containing the code to reproduce the analyses contained in our manuscript: Optimising expression quantitative trait locus mapping work...
cell type of the defined clusters (Fig.1a). Annotation of the cell-type of clusters is critical both to guide the clustering and to interpret the results of downstream analyses performed with respect to the clustering, such as differential expression testing [4] or single-cell eQTL mapping [5...