Down syndrome predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood1,2,3. Here, to understand dysregulated haematopoiesis in Down syndrome, we integrated single-cell transcr...
We apply single-cell transcriptomics to characterize the monocytes that are significantly enriched in the peripheral blood mononuclear cells (PBMC) of HAPH patients. We discover an increase in C1 (non-classical) and C2 (intermediate) monocytes in PBMCs and a decrease in hypoxia-inducible ...
In this work, we profile peripheral blood mononuclear cells (PBMCs) isolated from acute KD patients at single-cell resolution. We show that monocytes are the major source of pro-inflammatory mediators and could be a therapeutic target in PBMCs. Plasma cells and effector memory CD8+T cells are...
Figure 7 A showed the correlation between the five cell types and to what extent. The thicker the line, the closer the connection. As shown in Fig. 7B, B cells were mainly associated with T cells, NK cells and Monocytes, of which Monocyte was the most closely associated. As shown in ...
. Transcriptome analysis of peripheral blood mononuclear cells (PBMCs) was conducted using the 10x Genomics technique. We observed upregulation of genes likeCCDC15andTRBV4-2in T cells andCMPK2, IFIT1, andOAS2in monocytes in the SLE-C group. Notably, gene sets related to Cell Cycle and IFN...
We revealed five immune cell subsets: CD4+ T cells, CD8+ T cells, B cells, natural killer cells, and monocytes–macrophages cells, and disentangled the characteristic alterations of cell subset proportion and gene expression patterns in AD. Thirty-one cell type-specific key genes, comprising ...
Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. In addition, the recombinant human HuD protein was used to stimulate in vitro peripheral blood mononuclear cells of 10 seropositive patients and of 10 ... R Liblau - 《Annals of Neurology》 被引量: 527发...
(C) Bubble heatmap showed the mean interaction strength for the CXCL9 and CXCL10 interaction pairs of the M2 macrophages with other cell types. (D) 1 × 106 THP-1 human monocytes were treated with 150 nmol/L PMA for 24 hours, and were then treated with different concentrations of MDK ...
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spannin
Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of CSF leukocytes. Multiple sclerosis (MS) – an autoimmune disease of the CNS – increases transcriptional diversity in blood, but increases cell type diversity in CSF including a higher ...