THP-1 cells are a monocyte-like cell line derived from a patient with acute monocytic leukemia and unlike other leukemic cell lines has a normal diploid karyotype. We have characterized Fc-yRexpression on this cell line by flow cytometry, radiolabeled IgGi and monoclonal antibody (mAb) binding ...
This study reports a positive link between high thrombospondin-1 (THBS1) expression and mesenchymal characteristics, immunosuppression, and unfavorable CRC prognosis. Bone marrow-derived monocyte-like cells recruited by CXCL12 are the primary source of THBS1, which contributes to the ...
To examine the underlying mechanism by which THBS1 regulates T cell activity, we stimulated T cells isolated from the spleen with anti-CD3/CD28 antibodies in the presence of recombinant THBS1 (Fig.2m). Consistent with bulk RNA-seq data, showing enhanced IFNγ signaling in tumors inThbs1-/-m...
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment (TME) need to be identified to improve the outcome in CRC ...
Human immunodeficiency virus type 1 Nef in human monocyte-like cell line THP-1 expands treg cells via toll-like receptor 2. Qin Xiaolin,Yao Jiahong,Yang Fan,Nie Jiqin,Wang Yanlin,Liu Prof Chaoqi. Journal of cellular biochemistry . 2011
Atmospheric pressure oxygen plasma is used for generation of\nozone and endeavor to active macrophages those are a kind of immune cells. The effect of ozone on phagocytosis of macrophages is\ninvestigated by adjusting the irradiation time and ozone concentration. The phagocytosis increased 1.4 times ...
5-Lipoxygenase-activating Protein Gene Expression KEY ROLE OF CCAAT/ENHANCER-BINDING PROTEINS (C/EBP) IN CONSTITUTIVE AND TUMOR NECROSIS FACTOR (TNF) α-INDUCED EXPRESSION IN THP-1 CELLS We examined expression of the 5-lipoxygenase activating protein (FLAP), which is critical for inflammatory cell...
We found that mNI-11 recognizes an adhesion-associated molecule distinct from any previously reported in terms of its pattern of cellular distribution and molecular weight, and also found that mNI-11 has activity which induces cell adhesion/aggregation of U937 cells when stimulated with LPS. ICAM-...
Early Transcriptional Response of Human Monocyte-like THP-1 Cells in Response to Trichosporon asahii Infection Trichosporon asahii is the major cause of invasive trichosporonosis, but little is known about the host immune response to this pathogen. In this study, t... L Cong,Y Liao,X Lu,......
Nuclear run-on experiments show a time-dependent increase in the u-PAR gene transcription rate after exposure of the cells to PMA. The PMA-induced increase in u-PAR mRNA is paralleled by a time-dependent increase in u-PAR protein as detected by cross-linking studies with radiolabeled ligand....