neurons of AD patients.;Since mitochondrial structure in primary blood cells could be induced to appear identical to mitochondria in AD neurons and blood cells are affected in AD, our goal became to determine if morphological variation would be evident in AD blood cells and/or their mitochondria....
Because of their phagocytic activity and their ability to differentiate into antigen-presenting cells, monocytes participate in both innate and adaptive immune responses. They derive from bone-marrow progenitor cells, circulate in the blood as monocytes and differentiate into tissue macrophages or myeloid...
Jacquelin, S.,et al.CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice.Blood.122, 674-683 (2013). Swirski, F. K.,et al.Identification of splenic reservoir monocytes and their deployment to inflammatory sites.Science.325, 612-616 (...
Cells of the monocyte-macrophage lineage, which originate in the bone marrow (BM), are of particular importance in HIV-1 persistence due to their ability to cross the blood-brain barrier (BBB) and spread HIV-1 infection in the immunoprivileged central nervous system (CNS). Hematopoietic ...
Many cytokines, such as TNF-αand IL-1β have AU-rich elements (ARE) in their 3′U TR that are targeted by ARE-binding proteins which influence translation or transcript stability1–4. In addition, targeting of cytokine transcripts by miRNAs or lncRNAs has been described1. More...
The reproductive hormones are implicated in the well documented sexual dimorphism in cellular and immune responses. Prostaglandins (PGs) are mediators of the immune response with their concentration and relative amounts being pivotal to their impact. In resident peritoneal macrophages isolated from mice ...
Inflammatory responses could be mitigated by targeting pro-inflammatory cytokines or their receptors. Several trials using IL-1 inhibitors, IL-6 inhibitors, TNF-α inhibitors and JAK inhibitors are ongoing [103]. Interfering with massive monocyte infiltration can also attenuate local tissue inflammation....
First, monocytes are a circulatory, immune cell population, and their circulatory nature makes them easier targets for therapeutic modulation compared to targeting tissue-resident immune cells. Like other innate immune cells, monocytes have surface pattern recognition receptors (PRRs) that can bind to ...
(MPS). A term introduced by Van Furth that encompasses myeloid immune cells other than polymorphonuclear granulocytes and initially included monocytes and macrophages, and then, following their discovery, dendritic cells. microRNA (miRNA). A class of short endogenous non-coding RNAs that modulate the...
RNY genes account for four copies in human (RNY1, 3, 4 and 5) and two in mouse genome (RNY1 and 3), and their sequence is well conserved among vertebrates.12 The expression of s-RNYs is significantly upregulated in mouse models for atherosclerosis (namely the ApoE−/− and Ldlr...