Patient stratification based on cellular composition of the tumor microenvironment suggests distinct immune evasion mechanisms in colorectal cancer.doi:10.1038/s43018-024-00809-xNature Publishing Group USNature Cancer
The tumor microenvironment (TME) considerably influences colorectal cancer (CRC) progression, therapeutic response and clinical outcome, but studies of interindividual heterogeneities of the TME in CRC are lacking. Here, by integrating human colorectal single-cell transcriptomic data from approximately 200 ...
Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms of tum
”Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology“, “Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology“。 蔡立慧教授团队分别从细胞、遗传和机制层面,多角...
Most mutations were acquired during the final dominant clonal expansion of the cancer and resulted from mutational processes that are absent from normal colorectal cells. Intra-tumour diversification of DNA methylation and transcriptome states also occurred; these alterations were cell-autonomous, stable, ...
Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC) patients. How to improve therapeutic options for patients with metastatic CRC is the core question for CRC treatment. However, the complexity and diversity of stromal
A Single-Cell Atlas of Liver Metastases of Colorectal Cancer Reveals the Reprogramming of the Tumor Microenvironment in Response to Preoperative ChemotherapyMetastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC)... JM Li,LH Che,JW Liu,... - 《Cell Discovery》 被引...
对小鼠的研究已经使百科全书充满了突破性的医学发现。但是当涉及到脑癌时,这种小啮齿动物长期以来一直表现出基本的局限性。 其中包括:人类小脑的表面积是小鼠的750倍,所有这些表面积都布满了更多类型的祖细胞,…
Colorectal cancer Zhang et al. [20] mapped the T cell immunoreceptor of colorectal cancer by single-cell sequencing technology, and revealed the subgroup classification, tissue distribution characteristics, tumor heterogeneity and drug target gene expression of colorectal cancer T cells. A potential state...
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-cell transcriptomics data across six common can