The field of spatial transcriptomics is rapidly expanding, and with it the repertoire of available technologies. However, several of the transcriptome-wide spatial assays do not operate on a single cell level, but rather produce data comprised of contrib
Recent studies have emphasized the importance of single-cell spatial biology, yet available assays for spatial transcriptomics have limited gene recovery or low spatial resolution. Here we introduce CytoSPACE, an optimization method for mapping individua
In cancer, complex ecosystems of interacting cell types play fundamental roles in tumor development, progression, and response to therapy. However, the cellular organization, community structure, and spatially defined microenvironments of human tumors remain poorly understood. With the emergence of new ...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute to the initiation of oral squamous cell carcinoma (OSCC). However, the cellular compositions and spatial organization of the precancerous st
this is the idea that single-cell analysis should reflect how cells are organized in tissues. As familiar as this idea may seem, the toolkit to explore tissues spatially has been limited. But new technologies are making spatial biology a reality, ushering the field into a whole new era. Does...
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in health and disease. In less than a decade, the field has seen tremendous technological revolutions that enable crucial new insights into the ...
Here, we present detailed transcriptomic analysis of the various cell types of the developing human pancreas, including their spatial gene patterns. We integrated single-cell RNA sequencing with spatial transcriptomics at multiple developmental time points and revealed distinct temporal-spatial gene cascades...
And with the ability to multiplex single cells at a higher throughput, hundreds of single cells can be quantitatively analyzed in a single day, allowing researchers to efficiently and reliably determine the heterogeneity of a cell’s biology, unlocking never-before-seen insights that can...
A successful single-cell proteomics workflow hinges on throughput, quantitation, sensitivity, and coverage. In collaboration with the scientific community, Thermo Fisher Scientific innovates solutions that enable comprehensive single-cell proteomics analysis, revealing the full spectrum of cellular ...
英文题目:Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer 中文题目:单细胞分析定义了一个连续的细胞状态和成分变化,息肉恶性转化为结直肠癌 发表时间:2022-06-20 ...