However, the molecular factors and cell types involved in this complex interplay remain poorly understood. Here we developed a combined single cell and spatial transcriptomics approach to address this problem. Large-scale single-cell transcriptional profiling in conjunction with a multi-layered sorting ...
Advances and applications in single-cell and spatial genomics Jingjing Wang Fang Ye Zemin Zhang Science China Life Sciences (2024) Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes Iván Ballasch Laura López-Molina Albert Giralt Journ...
36,37]; (3) a probe-based method that counts barcode probes of known targets to obtain spatial information; and (4) image-guided spatially resolved single-cell RNA sequencing; in which individual cells in a region of
This study compared cartilage regeneration outcomes in knee osteoarthritis (OA) using allogeneic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation and microdrilling with high tibial osteotomy (HTO). Fifty-four patients (60 knees) were included: 24 (27 knees) in the ...
We applied a minimal preprocessing pipeline1 including motion correction and spatial normalization to the MNI space74 using the registration parameters obtained for the structural T1 image, and removal of the linear trend. We calculated the fractional amplitude of low-frequency fluctuations (fALFF)16, ...
Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy. Int J Mol Sci. 2020;21:7139. Article CAS PubMed PubMed Central Google Scholar Oh SA, Wu DC, Cheung J, Navarro A, Xiong H, Cubas R, et al. PD...
Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy. Int J Mol Sci. 2020;21:7139. Article CAS PubMed PubMed Central Google Scholar Oh SA, Wu DC, Cheung J, Navarro A, Xiong H, Cubas R, et al. PD...
Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:1277–84. Article CAS Google Scholar Bhuvanendran S, ...
Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer Yunfei Lu Yang Chen Zan Fu Journal of Translational Medicine (2025) Spatial analysis of a complete DIPG-infiltrated brainstem reveals novel ligand-receptor mediators of...
We concluded that the distribution of the single-cell adhesion force and energy can be fitted by log-normal functions as cells are spreading on the surface and revealed the dynamic changes in these distributions. The present methodology opens the way for the quantitative assessment of the kinetics...