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composomes (molecular aggregates with hereditary properties based on molecular complementarity), and a prebiotic ecology of co-evolving populations of composomes. In particular, we propose that SUMIs might limit the initial phenotype space of composomes in a coherent way. As examples...
Fundamental problems faced by the protocells and their modern descendants include how to go from one phenotypic state to another; escape from a basin of attraction in the space of phenotypes; reconcile conflicting growth and survival strategies (and ther
, which are characteristic of a biological process or of a specific phenotype. Bioinformatics methods and databases can be developed to provide solutions to challenges of handling massive amounts of data. The history of animal biotechnology with bioinformatics is to make a strong research community...
(3) Diffuse large B-cell lymphoma: proliferation of large lymphoma cells with nuclear size clearly exceeding a macrophage nucleus and often with greater nuclear pleomorphism regardless of im- munophenotype and genetic features. (4) Plasmablastic lymphoma: proliferation of large neoplastic cells with ...
Results: In this paper we present priority-Lasso, an intuitive and practical analysis strategy for building prediction models based on Lasso that takes such block structures into account. It requires the definition of a priority order of blocks of data. Lasso models are calculated successively for ...
of handwritten digits (aka biological phenotype, e.g. cell type in scRNAseq experiments) to comprisemost of the variationin the MNIST data, it probably makes sense to hypothesize thattwo tSNE/UMAP components are capabale of capturing more biological variation than two PCA components (at least ...
and in protein-coding sequences (CDSs), they can result in the phenotype modification [8,16–18], even lead to the generation of toxic or malfunctioning proteins [19]. For example, the expansion of the (GAG)nmotif in the coding region of the Huntington’s disease (HD) gene in humans ...
Regulatory gene circuit motifs play crucial roles in performing and maintaining vital cellular functions. Frequently, theoretical studies of gene circuits focus on steady-state behaviors and do not include time delays. In this study, the inclusion of tim
The definition of F-statistics used here is FST≡Q2-Q31-Q3, Where the Q are probabilities of identity in state, Q2 among genes in different individuals within groups (populations), and Q3 among groups (populations).The model-based program STRUCTURE 2.34 [69, 70] was used to infer ...